David Timm
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Explore the profile of David Timm including associated specialties, affiliations and a list of published articles.
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10
Citations
60
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Recent Articles
1.
Cashikar A, Toral-Rios D, Timm D, Romero J, Strickland M, Long J, et al.
J Lipid Res
. 2023 Feb;
64(4):100350.
PMID: 36849076
Neuroinflammation, a major hallmark of Alzheimer's disease and several other neurological and psychiatric disorders, is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express higher levels...
2.
Tonelli A, Aulak K, Ahmed M, Hausladen A, Abuhalimeh B, Casa C, et al.
PLoS One
. 2019 Aug;
14(8):e0221777.
PMID: 31469867
Rationale: Inhaled nitric oxide (NO) exerts a variety of effects through metabolites and these play an important role in regulation of hemodynamics in the body. A detailed investigation into the...
3.
Rogers S, Dosier L, McMahon T, Zhu H, Timm D, Zhang H, et al.
PLoS One
. 2018 Dec;
13(12):e0209201.
PMID: 30576340
Intact red blood cells (RBCs) are required for phenotypic analyses. In order to allow separation (time and location) between subject encounter and sample analysis, we developed a research-specific RBC cryopreservation...
4.
Bueno A, Agejas J, Broughton H, Dally R, Durham T, Espinosa J, et al.
J Med Chem
. 2017 Nov;
60(23):9807-9820.
PMID: 29088532
NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in...
5.
Dudutiene V, Zubriene A, Smirnov A, Gylyte J, Timm D, Manakova E, et al.
Bioorg Med Chem
. 2013 Feb;
21(7):2093-106.
PMID: 23394791
A series of 4-substituted-2,3,5,6-tetrafluorobenezenesulfonamides were synthesized and their binding potencies as inhibitors of recombinant human carbonic anhydrase isozymes I, II, VII, XII, and XIII were determined by the thermal shift...
6.
Vidal P, Timm D, Broughton H, Chen S, Martin J, Rivera-Sagredo A, et al.
J Med Chem
. 2005 Nov;
48(24):7623-7.
PMID: 16302802
Conformational analysis in solution of beta-secretase inhibitors 1 and 2 by NMR spectroscopy reveals that the hydroxyethylene isostere, an apparently flexible fragment widely used as a scissile bond replacement in...
7.
Rojo I, Martin J, Broughton H, Timm D, Erickson J, Yang H, et al.
Bioorg Med Chem Lett
. 2005 Oct;
16(1):191-5.
PMID: 16249081
The synthesis of novel macrocyclic peptidomimetic inhibitors of the enzyme BACE1 is described. These macrocycles are derived from a hydroxyethylene core structure. Compound 7 was co-crystallized with BACE1 and the...
8.
Chen S, LaMar J, Guo D, Kohn T, Yang H, McGee J, et al.
Bioorg Med Chem Lett
. 2003 Dec;
14(1):245-50.
PMID: 14684336
With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several...
9.
LaMar J, Hu J, Bueno A, Yang H, Guo D, Copp J, et al.
Bioorg Med Chem Lett
. 2003 Dec;
14(1):239-43.
PMID: 14684335
We describe herein the syntheses and evaluation of a series of C-termini pyridyl containing Phe*-Ala-based BACE inhibitors (5-19). In conjunction with four fixed residues at the P1 (Phe), P1' (Ala),...
10.
Hu J, Cwi C, Smiley D, Timm D, Erickson J, McGee J, et al.
Bioorg Med Chem Lett
. 2003 Dec;
13(24):4335-9.
PMID: 14643321
Utilizing structure-based techniques and solid-phase synthesis, statine-based tetrapeptide BACE inhibitors were designed and synthesized using a heptapeptide BACE transition-state mimetic, 1, as the starting point. Structure-activity relationship studies at the...