David T McSwiggen
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Explore the profile of David T McSwiggen including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
858
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Recent Articles
1.
Driouchi A, Bretan M, Davis B, Heckert A, Seeger M, Silva M, et al.
Nat Methods
. 2025 Feb;
22(3):559-568.
PMID: 39966678
An ideal tool for the study of cellular biology would enable the measure of molecular activity nondestructively within living cells. Single-molecule localization microscopy (SMLM) techniques, such as single-molecule tracking (SMT),...
2.
Quek R, Shirazinejad C, Young C, Hardy K, Lim S, Elms P, et al.
SLAS Discov
. 2025 Feb;
31:100220.
PMID: 39894078
Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules...
3.
Pino N, Sizemore A, Cleary L, Liu H, McSwiggen D, Song D, et al.
J Org Chem
. 2024 Jun;
89(20):14658-14664.
PMID: 38836310
Photoactivatable (PA) rhodamine dyes are widely used in single-molecule tracking (SMT) and a variety of other fluorescence-based imaging modalities. One of the most commonly employed scaffolds uses a diazoketone to...
4.
Wang A, Chen L, Wu R, Hao Y, McSwiggen D, Heckert A, et al.
Mol Cell
. 2020 Jul;
79(2):221-233.e5.
PMID: 32603710
Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to manipulate genomes in eukaryotic cells. Little is known about the...
5.
McSwiggen D, Mir M, Darzacq X, Tjian R
Genes Dev
. 2019 Oct;
33(23-24):1619-1634.
PMID: 31594803
The idea that liquid-liquid phase separation (LLPS) may be a general mechanism by which molecules in the complex cellular milieu may self-organize has generated much excitement and fervor in the...
6.
Pulos-Holmes M, Srole D, Juarez M, Lee A, McSwiggen D, Ingolia N, et al.
Elife
. 2019 Aug;
8.
PMID: 31414986
A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified...
7.
Boehning M, Dugast-Darzacq C, Rankovic M, Hansen A, Yu T, Marie-Nelly H, et al.
Nat Struct Mol Biol
. 2018 Aug;
25(9):833-840.
PMID: 30127355
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered low-complexity region that is critical for pre-mRNA transcription and processing. The CTD consists of hepta-amino acid repeats...
8.
Chen J, Tresenrider A, Chia M, McSwiggen D, Spedale G, Jorgensen V, et al.
Elife
. 2017 Sep;
6.
PMID: 28906249
Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes. How...
9.
Mutations in the promoter of the telomerase gene contribute to tumorigenesis by a two-step mechanism
Chiba K, Lorbeer F, Shain A, McSwiggen D, Schruf E, Oh A, et al.
Science
. 2017 Aug;
357(6358):1416-1420.
PMID: 28818973
promoter mutations (TPMs) are the most common noncoding mutations in cancer. The timing and consequences of TPMs have not been fully established. Here, we show that TPMs acquired at the...
10.
Ho J, Cattoglio C, McSwiggen D, Tjian R, Fong Y
Genes Dev
. 2017 May;
31(8):830-844.
PMID: 28512237
Faithful resetting of the epigenetic memory of a somatic cell to a pluripotent state during cellular reprogramming requires DNA methylation to silence somatic gene expression and dynamic DNA demethylation to...