David Sims
Overview
Explore the profile of David Sims including associated specialties, affiliations and a list of published articles.
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92
Citations
4000
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Recent Articles
11.
Hayward G, Gaborini L, Sims D, Schumacher Y, Millet G, Rhumorbarbe D, et al.
Drug Test Anal
. 2022 Jun;
14(9):1599-1613.
PMID: 35732071
The determinants of success in Olympic Games competition are specific to the athletic demands of the sporting event. A global evaluation to quantify the athletic demands across the spectrum of...
12.
Rajan D, Kour S, Fortuna T, Cousin M, Barnett S, Niu Z, et al.
Front Cell Dev Biol
. 2022 Mar;
10:783762.
PMID: 35295849
The hereditary ataxias are a heterogenous group of disorders with an increasing number of causative genes being described. Due to the clinical and genetic heterogeneity seen in these conditions, the...
13.
Li H, Janssens J, De Waegeneer M, Kolluru S, Davie K, Gardeux V, et al.
Science
. 2022 Mar;
375(6584):eabk2432.
PMID: 35239393
For more than 100 years, the fruit fly has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula , that...
14.
Downes D, Smith A, Karpinska M, Velychko T, Rue-Albrecht K, Sims D, et al.
Nat Protoc
. 2022 Feb;
17(2):445-475.
PMID: 35121852
Chromosome conformation capture (3C) methods measure the spatial proximity between DNA elements in the cell nucleus. Many methods have been developed to sample 3C material, including the Capture-C family of...
15.
Tanudjojo B, Shaikh S, Fenyi A, Bousset L, Agarwal D, Marsh J, et al.
Nat Commun
. 2021 Jun;
12(1):3817.
PMID: 34155194
α-Synuclein is critical in the pathogenesis of Parkinson's disease and related disorders, yet it remains unclear how its aggregation causes degeneration of human dopaminergic neurons. In this study, we induced...
16.
Chen A, Kummar S, Moore N, Rubinstein L, Zhao Y, Williams P, et al.
JCO Precis Oncol
. 2021 Apr;
5.
PMID: 33928209
Materials And Methods: Adult patients with an actionable mutation of interest were randomly assigned 2:1 to receive either (1) a study regimen identified to target the aberrant pathway found in...
17.
Zhang P, Kitchen-Smith I, Xiong L, Stracquadanio G, Brown K, Richter P, et al.
Cancer Res
. 2021 Feb;
81(7):1667-1680.
PMID: 33558336
Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic insights have thus far been limited...
18.
Lovell J, MacQueen A, Mamidi S, Bonnette J, Jenkins J, Napier J, et al.
Nature
. 2021 Jan;
590(7846):438-444.
PMID: 33505029
Long-term climate change and periodic environmental extremes threaten food and fuel security and global crop productivity. Although molecular and adaptive breeding strategies can buffer the effects of climatic stress and...
19.
Villegas-Mendez A, Khandelwal G, McGowan L, Dookie R, Haley M, George C, et al.
J Immunol
. 2020 Aug;
205(6):1608-1619.
PMID: 32817333
CD4 T cell functional inhibition (exhaustion) is a hallmark of malaria and correlates with impaired parasite control and infection chronicity. However, the mechanisms of CD4 T cell exhaustion are still...
20.
Ababneh N, Scaber J, Flynn R, Douglas A, Barbagallo P, Candalija A, et al.
Hum Mol Genet
. 2020 Jun;
29(13):2200-2217.
PMID: 32504093
The G4C2 hexanucleotide repeat expansion (HRE) in C9orf72 is the commonest cause of familial amyotrophic lateral sclerosis (ALS). A number of different methods have been used to generate isogenic control...