David Shugar
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Explore the profile of David Shugar including associated specialties, affiliations and a list of published articles.
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42
Citations
456
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Recent Articles
11.
Shugar D, Fabbro D
Biochim Biophys Acta
. 2013 Jun;
1834(7):1269-70.
PMID: 23764324
No abstract available.
12.
Poznanski J, Shugar D
Biochim Biophys Acta
. 2013 Feb;
1834(7):1381-6.
PMID: 23376187
Halogenated ligands have been widely developed as potent, and frequently selective, inhibitors of protein kinases (PK). Herein, all structures of protein kinases complexed with a halogenated ligand, identified in the...
13.
Gasik Z, Shugar D, Antosiewicz J
Curr Pharm Des
. 2012 Nov;
19(23):4226-40.
PMID: 23170881
We herein review experimental and theoretical approaches widely applied to delineation of the differences in substrate specificities between human and parasite phosphoribosyltransferases (PRTases), the latter of which are key targets...
14.
Wasik R, Winska P, Poznanski J, Shugar D
PLoS One
. 2012 Nov;
7(11):e48898.
PMID: 23155426
To further clarify the role of the individual bromine atoms of 4,5,6,7-tetrabromotriazole (TBBt), a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition (IC(50)) of human CK2α...
15.
Wasik R, Winska P, Poznanski J, Shugar D
J Phys Chem B
. 2012 May;
116(24):7259-68.
PMID: 22632480
In ongoing studies on the role of the individual bromine atoms of 4,5,6,7-tetrabromobenzotriazole (TBBt) in its relatively selective inhibition of protein kinase CK2α, we have prepared all the possible two...
16.
Antosiewicz J, Shugar D
Mol Biosyst
. 2011 Aug;
7(11):2923-49.
PMID: 21858282
All molecules can be viewed as either discrete or continuous assemblies of electric charges, and electrostatics plays a major role in intermolecular and intramolecular interactions. Moreover, charge distribution within molecules...
17.
Wasik R, Lebska M, Felczak K, Poznanski J, Shugar D
J Phys Chem B
. 2010 Aug;
114(32):10601-11.
PMID: 20734498
To examine the relative role of halogen bonding and hydrophobic interactions in the inhibition of human CK2alpha by 4,5,6,7-tetrabromobenzotriazole (TBBt), we have synthesized a series of 5-substituted benzotriazoles (Bt) and...
18.
Fraczyk T, Kubinski K, Maslyk M, Ciesla J, Hellman U, Shugar D, et al.
Bioorg Chem
. 2010 Mar;
38(3):124-31.
PMID: 20199796
Thymidylate synthase (TS) was found to be a substrate for both catalytic subunits of human CK2, with phosphorylation by CK2alpha and CK2alpha' characterized by similar K(m) values, 4.6microM and 4.2microM,...
19.
20.
Medza G, Wierzchowski J, Kierdaszuk B, Shugar D
Bioorg Med Chem
. 2009 Mar;
17(6):2585-91.
PMID: 19250833
Fluorescence emission properties of 8-azacaffeine, 8-azatheophylline and other N-alkylated 8-azaxanthines (8-azaXan) have been examined. It is shown that N-methylated 8-azaxanthines, as well as 8-azatheophylline, are highly fluorescent in aqueous medium...