David Sedwick
Overview
Explore the profile of David Sedwick including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
318
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0
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Recent Articles
1.
Nandadasa S, Szafron J, Pathak V, Murtada S, Kraft C, ODonnell A, et al.
Elife
. 2020 Sep;
9.
PMID: 32909945
The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified...
2.
Hao Y, Wang C, Cao B, Hirsch B, Song J, Markowitz S, et al.
Cancer Cell
. 2013 May;
23(5):583-93.
PMID: 23643389
PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase α, is frequently mutated in human cancers. Most of these mutations occur at two hot-spots: E545K and H1047R located in...
3.
Zhang P, Zhao Y, Zhu X, Sedwick D, Zhang X, Wang Z
Mol Cancer Res
. 2011 Aug;
9(10):1418-28.
PMID: 21840932
Hyperphosphorylation at the Y705 residue of signal transducer and activator of transcription 3 (STAT3) is implicated in tumorigenesis of leukemia and some solid tumors. However, its role in the development...
4.
Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, et al.
Sci Signal
. 2010 Nov;
3(146):ra80.
PMID: 21045206
DNA methyltransferase 1 (DNMT1) is the primary enzyme that maintains DNA methylation. We describe a previously unknown mode of regulation of DNMT1 protein stability through the coordinated action of an...
5.
Li L, Morales J, Veigl M, Sedwick D, Greer S, Meyers M, et al.
Br J Pharmacol
. 2009 Sep;
158(3):679-92.
PMID: 19775280
The metabolism and efficacy of 5-fluorouracil (FUra) and other fluorinated pyrimidine (FP) derivatives have been intensively investigated for over fifty years. FUra and its antimetabolites can be incorporated at RNA-...