David S Eisenberg
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Explore the profile of David S Eisenberg including associated specialties, affiliations and a list of published articles.
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91
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Recent Articles
11.
Seidler P, Murray K, Boyer D, Ge P, Sawaya M, Hu C, et al.
Nat Commun
. 2022 Sep;
13(1):5451.
PMID: 36114178
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a therapeutic...
12.
Bowler J, Sawaya M, Boyer D, Cascio D, Bali M, Eisenberg D
J Biol Chem
. 2022 Aug;
298(10):102396.
PMID: 35988647
Amyloid protein aggregation is commonly associated with progressive neurodegenerative diseases, however not all amyloid fibrils are pathogenic. The neuronal cytoplasmic polyadenylation element binding protein is a regulator of synaptic mRNA...
13.
Murray K, Hu C, Griner S, Pan H, Bowler J, Abskharon R, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2206240119.
PMID: 35969734
Neurodegenerative diseases are characterized by the pathologic accumulation of aggregated proteins. Known as amyloid, these fibrillar aggregates include proteins such as tau and amyloid-β (Aβ) in Alzheimer's disease (AD) and...
14.
Murray K, Hughes M, Hu C, Sawaya M, Salwinski L, Pan H, et al.
Nat Struct Mol Biol
. 2022 May;
29(6):529-536.
PMID: 35637421
Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils through interactions of their low-complexity domains (LCDs). Mutations in LCDs can promote irreversible amyloid aggregation and disease. We introduce...
15.
Rosenberg G, Murray K, Salwinski L, Hughes M, Abskharon R, Eisenberg D
J Biol Chem
. 2022 Apr;
298(5):101920.
PMID: 35405097
Low-complexity domains (LCDs) of proteins have been shown to self-associate, and pathogenic mutations within these domains often drive the proteins into amyloid aggregation associated with disease. These domains may be...
16.
Abskharon R, Sawaya M, Boyer D, Cao Q, Nguyen B, Cascio D, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(15):e2119952119.
PMID: 35377792
In neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, proteins that bind RNA are found in aggregated forms in autopsied brains. Evidence suggests that RNA aids nucleation of these pathological...
17.
Jiang Y, Cao Q, Sawaya M, Abskharon R, Ge P, DeTure M, et al.
Nature
. 2022 Mar;
605(7909):304-309.
PMID: 35344984
Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 year olds with behavioural changes or progressive...
18.
Gray A, Sawaya M, Acharyya D, Lou J, Edington E, Best M, et al.
Protein Sci
. 2021 Dec;
31(3):716-727.
PMID: 34954854
Atomic structures of amyloid oligomers that capture the neurodegenerative disease pathology are essential to understand disease-state causes and finding cures. Here we investigate the G6W mutation of the cytotoxic, hexameric...
19.
Hughes M, Goldschmidt L, Eisenberg D
J Biol Chem
. 2021 Sep;
297(4):101194.
PMID: 34537246
Membraneless organelles (MLOs) are vital and dynamic reaction centers in cells that compartmentalize the cytoplasm in the absence of a membrane. Multivalent interactions between protein low-complexity domains contribute to MLO...
20.
Sawaya M, Hughes M, Rodriguez J, Riek R, Eisenberg D
Cell
. 2021 Sep;
184(19):4857-4873.
PMID: 34534463
The hidden world of amyloid biology has suddenly snapped into atomic-level focus, revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular proteins, amyloid proteins flatten and stack...