David S Donaldson
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Explore the profile of David S Donaldson including associated specialties, affiliations and a list of published articles.
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20
Citations
469
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Recent Articles
1.
Donaldson D, Shih B, Mabbott N
Front Immunol
. 2021 Dec;
12:761949.
PMID: 34938288
The decline in mucosal immunity during aging increases susceptibility, morbidity and mortality to infections acquired the gastrointestinal and respiratory tracts in the elderly. We previously showed that this immunosenescence includes...
2.
Mabbott N, Bradford B, Pal R, Young R, Donaldson D
Int J Mol Sci
. 2020 Oct;
21(19).
PMID: 33023255
Prion diseases are a unique group of infectious chronic neurodegenerative disorders to which there are no cures. Although prion infections do not stimulate adaptive immune responses in infected individuals, the...
3.
Donaldson D, Pollock J, Vohra P, Stevens M, Mabbott N
iScience
. 2020 May;
23(6):101147.
PMID: 32454449
Aging has a profound effect on the immune system, termed immunosenescence, resulting in increased incidence and severity of infections and decreased efficacy of vaccinations. We previously showed that immunosurveillance in...
4.
Donaldson D, Bradford B, Else K, Mabbott N
Sci Rep
. 2020 Mar;
10(1):4554.
PMID: 32165661
Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. Therefore, we used the gastrointestinal helminth pathogen Trichuris...
5.
Balic A, Chintoan-Uta C, Vohra P, Sutton K, Cassady-Cain R, Hu T, et al.
Front Immunol
. 2019 Nov;
10:2495.
PMID: 31695701
The follicle-associated epithelium (FAE) is a specialized structure that samples luminal antigens and transports them into mucosa-associated lymphoid tissues (MALT). In mammals, transcytosis of antigens across the gut epithelium is...
6.
Sanchez-Quintero A, Bradford B, Maizels R, Donaldson D, Mabbott N
Sci Rep
. 2019 May;
9(1):6674.
PMID: 31040320
The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) within the small intestinal Peyer's patches is essential to establish host infection, and for the disease...
7.
Bradford B, Donaldson D, Forman R, Else K, Mabbott N
Parasite Immunol
. 2018 Jun;
40(8):e12566.
PMID: 29920694
Trichuris muris is a natural mouse helminth pathogen which establishes infection specifically in the caecum and proximal colon. The rapid expulsion of T. muris in resistant mouse strains is associated...
8.
Sehgal A, Donaldson D, Pridans C, Sauter K, Hume D, Mabbott N
Nat Commun
. 2018 Mar;
9(1):1272.
PMID: 29593242
Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but...
9.
Donaldson D, Sehgal A, Rios D, Williams I, Mabbott N
PLoS Pathog
. 2016 Dec;
12(12):e1006075.
PMID: 27973593
Many natural prion diseases of humans and animals are considered to be acquired through oral consumption of contaminated food or pasture. Determining the route by which prions establish host infection...
10.
Sehgal A, Kobayashi A, Donaldson D, Mabbott N
Immunobiology
. 2016 Sep;
222(2):316-326.
PMID: 27663963
M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid tissues. These unique phagocytic epithelial cells enable the mucosal immune system to sample antigens within the lumen of...