David S DeLuca
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Explore the profile of David S DeLuca including associated specialties, affiliations and a list of published articles.
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47
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3494
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Recent Articles
1.
Liu B, Rosenhahn B, Illig T, DeLuca D
PLoS Comput Biol
. 2024 Jul;
20(7):e1011198.
PMID: 38959284
Interpreting transcriptome data is an important yet challenging aspect of bioinformatic analysis. While gene set enrichment analysis is a standard tool for interpreting regulatory changes, we utilize deep learning techniques,...
2.
Pradhan P, Vijayan V, Liu B, Martinez-Delgado B, Matamala N, Nikolin C, et al.
Redox Biol
. 2024 May;
73:103191.
PMID: 38762951
Activation of inflammation is tightly associated with metabolic reprogramming in macrophages. The iron-containing tetrapyrrole heme can induce pro-oxidant and pro-inflammatory effects in murine macrophages, but has been associated with polarization...
3.
Sivaraman K, Liu B, Martinez-Delgado B, Held J, Buttner M, Illig T, et al.
Lung
. 2024 Mar;
202(2):157-170.
PMID: 38494528
Purpose: To investigate the transcriptome of human bronchial epithelial cells (HBEC) in response to serum from patients with different degrees of inflammation. Methods: Serum from 19 COVID-19 patients obtained from...
4.
Lechowicz U, Martinez-Delgado B, Liu B, Wrenger S, Rozy A, Zdral A, et al.
Clin Biochem
. 2024 Mar;
126:110736.
PMID: 38428450
Introduction: Compared to normal PiMM, individuals with severe α1-antitrypsin (AAT) PiZZ (Glu342Lys) genotype deficiency are at higher risk of developing early-onset chronic obstructive pulmonary disease (COPD)/emphysema associated with Z-AAT polymers...
5.
Schukfeh N, Liu B, DeLuca D, Tumpara S, Nikolin C, Immenschuh S, et al.
Eur J Immunol
. 2022 Nov;
53(1):e2250019.
PMID: 36321537
Nowadays laparoscopic interventions enable the collection of resident macrophage populations out of the human cavities. We employed this technique to isolate pleural monocytes/macrophages from healthy young adults who underwent a...
6.
Meghadri S, Martinez-Delgado B, Ostermann L, Gomez-Mariano G, Perez-Luz S, Tumpara S, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142337
The gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80-90%) produced in the liver. Point mutations in the gene can lead to the...
7.
Grunding A, Schneider M, Richtmann S, Kriegsmann M, Winter H, Martinez-Delgado B, et al.
Cancers (Basel)
. 2022 Sep;
14(18).
PMID: 36139614
To explore the relationship between cancer cell SREBF1 expression, lipid droplets (LDs) formation, and the sensitivity to chemotherapies, we cultured lung adenocarcinoma cells H1299 (with LD) and H1563 (without LD)...
8.
Gaedcke S, Sinning J, Dittrich-Breiholz O, Haller H, Soerensen-Zender I, Liao C, et al.
Am J Physiol Renal Physiol
. 2022 May;
323(2):F171-F181.
PMID: 35635323
The kidney is a complex organ, which consists of multiple components with highly diverse cell types. A detailed understanding of these cell types in health and disease is crucial for...
9.
Vajen B, Bhowmick R, Greiwe L, Schaffer V, Eilers M, Reinkens T, et al.
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563522
Chromosomal instability (CIN) can be a driver of tumorigenesis but is also a promising therapeutic target for cancer associated with poor prognosis such as triple negative breast cancer (TNBC). The...
10.
Maison N, Omony J, Illi S, Thiele D, Skevaki C, Dittrich A, et al.
Eur Respir J
. 2022 Feb;
60(3).
PMID: 35210326
Rationale: In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. Objectives: To define T2-high...