David R Piper
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Explore the profile of David R Piper including associated specialties, affiliations and a list of published articles.
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14
Citations
470
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Recent Articles
1.
Llamosas N, Arora V, Vij R, Kilinc M, Bijoch L, Rojas C, et al.
J Neurosci
. 2020 Sep;
40(41):7980-7994.
PMID: 32887745
is a major genetic risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy. loss-of-function variants in this gene cause a neurodevelopmental disorder defined by cognitive impairment, social-communication...
2.
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera F, Willems E, et al.
Sci Rep
. 2019 Jun;
9(1):9000.
PMID: 31227747
Neurons created from human induced pluripotent stem cells (hiPSCs) provide the capability of identifying biological mechanisms that underlie brain disorders. IPSC-derived human neurons, or iNs, hold promise for advancing precision...
3.
Suri A, Bailey A, Tavares M, Gunosewoyo H, Dyer C, Grupenmacher A, et al.
Int J Mol Sci
. 2019 May;
20(9).
PMID: 31035676
Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and...
4.
Treiger Sredni S, Bailey A, Suri A, Hashizume R, He X, Louis N, et al.
Oncotarget
. 2018 Jan;
8(67):111190-111212.
PMID: 29340047
Rhabdoid tumors (RT) are highly aggressive and vastly unresponsive embryonal tumors. They are the most common malignant CNS tumors in infants below 6 months of age. Medulloblastomas (MB) are embryonal...
5.
Treiger Sredni S, Suzuki M, Yang J, Topczewski J, Bailey A, Gokirmak T, et al.
Pediatr Blood Cancer
. 2017 Apr;
64(11).
PMID: 28398638
Purpose: Malignant rhabdoid tumors (MRTs) are deadly embryonal tumors of the infancy. With poor survival and modest response to available therapies, more effective and less toxic treatments are needed. We...
6.
Matheny Jr R, Riddle-Kottke M, Leandry L, Lynch C, Abdalla M, Geddis A, et al.
Mol Cell Biol
. 2015 Jan;
35(7):1182-96.
PMID: 25605332
Phosphoinositide 3-OH kinase (PI3K) regulates a number of developmental and physiologic processes in skeletal muscle; however, the contributions of individual PI3K p110 catalytic subunits to these processes are not well-defined....
7.
Piper D, Duff S, Eliason H, Frazee W, Frey E, Fuerstenau-Sharp M, et al.
Assay Drug Dev Technol
. 2008 May;
6(2):213-23.
PMID: 18471075
The life-threatening consequences of acquired, or drug-induced, long QT syndrome due to block of the human ether-a-go-go-related gene (hERG) channel are well appreciated and have been the cause of several...
8.
Piper D, Rupp J, Sachse F, Sanguinetti M, Tristani-Firouzi M
Cell Physiol Biochem
. 2008 Jan;
21(1-3):37-46.
PMID: 18209470
HERG1 K(+) channels are critical for modulating the duration of the cardiac action potential. The role of hERG1 channels in maintaining electrical stability in the heart derives from their unusual...
9.
Ferrer T, Rupp J, Piper D, Tristani-Firouzi M
J Biol Chem
. 2006 Mar;
281(18):12858-64.
PMID: 16524878
A key unresolved question regarding the basic function of voltage-gated ion channels is how movement of the voltage sensor is coupled to channel opening. We previously proposed that the S4-S5...
10.
Hong K, Piper D, Diaz-Valdecantos A, Brugada J, Oliva A, Burashnikov E, et al.
Cardiovasc Res
. 2005 Aug;
68(3):433-40.
PMID: 16109388
Objective: We describe a genetic basis for atrial fibrillation and short QT syndrome in utero. Heterologous expression of the mutant channel was used to define the physiological consequences of the...