Gavin Rumbaugh
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Explore the profile of Gavin Rumbaugh including associated specialties, affiliations and a list of published articles.
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70
Citations
4018
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Recent Articles
1.
Vaissiere T, Michaelson S, Creson T, Goins J, Furth D, Balazsfi D, et al.
Nat Commun
. 2025 Jan;
16(1):812.
PMID: 39827187
Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice that expression of the autism/intellectual...
2.
Radnai L, Young E, Kikuti C, Hafenbreidel M, Stremel R, Lin L, et al.
bioRxiv
. 2024 Oct;
PMID: 39416074
Highlights: Research suggests numerous indications, from axon regeneration and cancer, would benefit from a small molecule inhibitor of non-muscle myosin II, a molecular motor that regulates the actin cytoskeleton. Current...
3.
Haetzel L, Iafrati J, Cording K, Farhan M, Noveir S, Rumbaugh G, et al.
J Neurosci
. 2024 Oct;
44(48).
PMID: 39358043
is a high-confidence autism spectrum disorder (ASD) risk gene, and mutations in lead to a neurodevelopmental disorder (NDD) that presents with epilepsy, ASD, motor developmental delay, and intellectual disability. codes...
4.
Kenchappa R, Radnai L, Young E, Zarco N, Lin L, Dovas A, et al.
bioRxiv
. 2024 May;
PMID: 38746089
Highlights: MT-125 is a highly specific small molecule inhibitor of non-muscle myosin IIA and IIB, is well-tolerated, and achieves therapeutic concentrations in the brain with systemic dosing.Treating preclinical models of...
5.
Hafenbreidel M, Pandey S, Briggs S, Arza M, Bonthu S, Fisher C, et al.
Neurobiol Learn Mem
. 2023 Nov;
206:107865.
PMID: 37995804
Preclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of...
6.
Birtele M, Del Dosso A, Xu T, Nguyen T, Wilkinson B, Hosseini N, et al.
Nat Neurosci
. 2023 Nov;
26(12):2090-2103.
PMID: 37946050
Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has been implicated as a convergent mechanism in ASD pathophysiology,...
7.
Lovelace J, Ma J, Yadav S, Chhabria K, Shen H, Pang Z, et al.
Nature
. 2023 Nov;
623(7986):387-396.
PMID: 37914931
Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders. The Bezold-Jarisch reflex (BJR), first described in 1867, is a cardioinhibitory reflex that is speculated...
8.
Vaissiere T, Michaelson S, Creson T, Goins J, Furth D, Balazsfi D, et al.
bioRxiv
. 2023 Oct;
PMID: 37808765
Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice that expression of the autism/intellectual...
9.
Hafenbreidel M, Briggs S, Arza M, Bonthu S, Fisher C, Tiller A, et al.
bioRxiv
. 2023 Jun;
PMID: 37292925
Inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory. The...
10.
Kilinc M, Arora V, Creson T, Rojas C, Le A, Lauterborn J, et al.
Elife
. 2022 Apr;
11.
PMID: 35394425
Loss-of-function variants in cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellular functions of...