David R Piper
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Explore the profile of David R Piper including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
470
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Recent Articles
11.
Piper D, Sanguinetti M, Tristani-Firouzi M
Novartis Found Symp
. 2005 Jul;
266:46-52.
PMID: 16050261
The critical role of hERG in the maintenance of normal cardiac electrical activity derives from its unusual gating properties: slow channel activation and fast inactivation. To characterize voltage sensor movement...
12.
Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating
Piper D, Hinz W, Tallurri C, Sanguinetti M, Tristani-Firouzi M
J Biol Chem
. 2004 Nov;
280(8):7206-17.
PMID: 15528201
Slow activation and rapid C-type inactivation produce inward rectification of the current-voltage relationship for human ether-a'-go-go-related gene (hERG) channels. To characterize the voltage sensor movement associated with hERG activation and...
13.
Piper D, Varghese A, Sanguinetti M, Tristani-Firouzi M
Proc Natl Acad Sci U S A
. 2003 Aug;
100(18):10534-9.
PMID: 12928493
HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K+ channel vital to normal repolarization of cardiac action potentials. Attenuation of repolarizing K+ current caused by mutations in HERG or channel...
14.
Chen J, Piper D, Sanguinetti M
Trends Cardiovasc Med
. 2002 Feb;
12(1):42-5.
PMID: 11796244
Activation of pacemaker channels underlie the spontaneous diastolic depolarization of sinoatrial node cells in the heart. Four similar genes encoding these hyperpolarization-activated, cyclic nucleotide-gated channels were recently cloned and subsequently...