David R Pease
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Explore the profile of David R Pease including associated specialties, affiliations and a list of published articles.
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12
Citations
167
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Recent Articles
1.
Giammona A, De Vellis C, Crivaro E, Maresca L, Amoriello R, Ricci F, et al.
J Exp Clin Cancer Res
. 2024 Aug;
43(1):214.
PMID: 39090759
Background: Melanoma progression is based on a close interaction between cancer cells and immune cells in the tumor microenvironment (TME). Thus, a better understanding of the mechanisms controlling TME dynamics...
2.
Sigafoos A, Tolosa E, Carr R, Fernandez-Barrena M, Almada L, Pease D, et al.
Cancer Res Commun
. 2024 Jun;
4(7):1677-1689.
PMID: 38896052
Aberrant activation of GLI transcription factors has been implicated in the pathogenesis of different tumor types including pancreatic ductal adenocarcinoma. However, the mechanistic link with established drivers of this disease...
3.
Paradise B, Gainullin V, Almada L, Sigafoos A, Sen S, Vera R, et al.
Biochem J
. 2023 Jul;
480(15):1199-1216.
PMID: 37477952
Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. One well-established mechanism of this...
4.
Clemens D, Ye D, Zhou W, Kim C, Pease D, Navaratnarajah C, et al.
PLoS One
. 2023 Mar;
18(3):e0282151.
PMID: 36888581
Background: SARS-CoV-2-mediated COVID-19 may cause sudden cardiac death (SCD). Factors contributing to this increased risk of potentially fatal arrhythmias include thrombosis, exaggerated immune response, and treatment with QT-prolonging drugs. However,...
5.
Almada L, Barroso K, Sen S, Toruner M, Sigafoos A, Raja Arul G, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Feb;
1866(2):194924.
PMID: 36842643
Upon accumulation of improperly folded proteins in the Endoplasmic Reticulum (ER), the Unfolded Protein Response (UPR) is triggered to restore ER homeostasis. The induction of stress genes is a sine...
6.
Pease D, Fernandez-Zapico M
Cancer Res
. 2021 Nov;
81(22):5608-5610.
PMID: 34782322
The importance of the cross-talk between the genetic and epigenetic alterations promoting cancer development is well understood; however, the molecular details underlying the mechanism of how oncogenic signaling remodels the...
7.
Navaratnarajah C, Pease D, Halfmann P, Taye B, Barkhymer A, Howell K, et al.
J Virol
. 2021 Oct;
95(24):e0136821.
PMID: 34613786
Severe cardiovascular complications can occur in coronavirus disease of 2019 (COVID-19) patients. Cardiac damage is attributed mostly to the aberrant host response to acute respiratory infection. However, direct infection of...
8.
Park J, Daniels J, Wartewig T, Ringbloom K, Martinez-Escala M, Choi S, et al.
Blood
. 2021 Jun;
138(14):1225-1236.
PMID: 34115827
Cutaneous T-cell lymphomas (CTCLs) are a clinically heterogeneous collection of lymphomas of the skin-homing T cell. To identify molecular drivers of disease phenotypes, we assembled representative samples of CTCLs from...
9.
Schneider J, Oommen S, Qureshi M, Goetsch S, Pease D, Sundsbak R, et al.
Nat Med
. 2021 Jun;
27(7):1309.
PMID: 34079106
No abstract available.
10.
Schneider J, Oommen S, Qureshi M, Goetsch S, Pease D, Sundsbak R, et al.
Nat Med
. 2020 Nov;
26(11):1788-1800.
PMID: 33188278
Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated droplets that organize and manage messenger RNA metabolism, cell signaling, biopolymer assembly, biochemical reactions and stress granule responses to cellular adversity. Dysregulated RNP...