David R Jackson
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Explore the profile of David R Jackson including associated specialties, affiliations and a list of published articles.
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12
Citations
264
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Recent Articles
1.
Kwon J, Bae M, Szamosvari D, Cassilly C, Bolze A, Jackson D, et al.
J Am Chem Soc
. 2023 Mar;
145(13):7071-7074.
PMID: 36952265
Some members of the human gut microbiota profoundly influence their host's physiology, health, and therapeutic responses, but the responsible molecules and mechanisms are largely unknown. As part of a project...
2.
Jackson D, Cassilly C, Plichta D, Vlamakis H, Liu H, Melville S, et al.
ACS Chem Biol
. 2020 Dec;
16(1):6-13.
PMID: 33350306
Plasmalogens are vinyl ether-containing lipids produced by mammals and bacteria. The aerobic biosynthetic pathway in eukaryotes and bacteria is known, but the anaerobic pathway has remained a mystery. Here, we...
3.
Milligan J, Lee D, Jackson D, Schaub A, Beld J, Barajas J, et al.
Nat Chem Biol
. 2019 Jun;
15(7):669-671.
PMID: 31209348
Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the Escherichia coli acyl carrier protein (AcpP) and β-ketoacyl-ACP-synthase...
4.
Jackson D, Shakya G, Patel A, Mohammed L, Vasilakis K, Wattana-Amorn P, et al.
ACS Chem Biol
. 2017 Nov;
13(1):141-151.
PMID: 29161022
Daunorubicin is a type II polyketide, one of a large class of polyaromatic natural products with anticancer, antibiotic, and antiviral activity. Type II polyketides are formed by the assembly of...
5.
Barajas J, Shakya G, Moreno G, Rivera Jr H, Jackson D, Topper C, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(21):E4142-E4148.
PMID: 28484029
Product template (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates assembled during the catalytic cycle. Our ability to understand the...
6.
Valentic T, Jackson D, Brady S, Tsai S
ACS Chem Biol
. 2016 Oct;
11(12):3421-3430.
PMID: 27779377
Arixanthomycins are pentangular polyphenols (PP) with potent antiproliferative activities that were discovered through the heterologous expression of environmental DNA-derived gene clusters. The biosynthesis of arixanthomycin and other PPs is unusual...
7.
Jackson D, Yu X, Wang G, Patel A, Calveras J, Barajas J, et al.
ACS Chem Biol
. 2016 Jan;
11(4):1137-47.
PMID: 26813028
Cores of aromatic polyketides are essential for their biological activities. Most type II polyketide synthases (PKSs) biosynthesize these core structures involving the minimal PKS, a PKS-associated ketoreductase (KR) and aromatases/cyclases...
8.
Caldara-Festin G, Jackson D, Barajas J, Valentic T, Patel A, Aguilar S, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(50):E6844-51.
PMID: 26631750
Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization patterns that are crucial...
9.
Finzel K, Nguyen C, Jackson D, Gupta A, Tsai S, Burkart M
Chem Biol
. 2015 Nov;
22(11):1453-1460.
PMID: 26526101
Microbial fatty acid biosynthetic enzymes are important targets for areas as diverse as antibiotic development to biofuel production. Elucidating the molecular basis of chain length control during fatty acid biosynthesis...
10.
Jackson D, Tu S, Nguyen M, Barajas J, Schaub A, Krug D, et al.
ACS Chem Biol
. 2015 Oct;
11(1):95-103.
PMID: 26473393
The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic strategies for the incorporation of nonacetate starter units in type...