David R Cheng
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Explore the profile of David R Cheng including associated specialties, affiliations and a list of published articles.
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5
Citations
644
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Recent Articles
1.
McGaw C, Garrity A, Munoz G, Haswell J, Sengupta S, Keston-Smith E, et al.
Nat Commun
. 2022 May;
13(1):2833.
PMID: 35595757
The CRISPR-Cas type V-I is a family of Cas12i-containing programmable nuclease systems guided by a short crRNA without requirement for a tracrRNA. Here we present an engineered Type V-I CRISPR...
2.
Allen W, Altae-Tran H, Briggs J, Jin X, McGee G, Shi A, et al.
Nat Hum Behav
. 2020 Aug;
4(9):972-982.
PMID: 32848231
Despite the widespread implementation of public health measures, coronavirus disease 2019 (COVID-19) continues to spread in the United States. To facilitate an agile response to the pandemic, we developed How...
3.
Faure G, Shmakov S, Yan W, Cheng D, Scott D, Peters J, et al.
Nat Rev Microbiol
. 2019 Jun;
17(8):513-525.
PMID: 31165781
The principal function of CRISPR-Cas systems in archaea and bacteria is defence against mobile genetic elements (MGEs), including viruses, plasmids and transposons. However, the relationships between CRISPR-Cas and MGEs are...
4.
Yan W, Hunnewell P, Alfonse L, Carte J, Keston-Smith E, Sothiselvam S, et al.
Science
. 2018 Dec;
363(6422):88-91.
PMID: 30523077
Type V CRISPR-Cas systems are distinguished by a single RNA-guided RuvC domain-containing effector, Cas12. Although effectors of subtypes V-A (Cas12a) and V-B (Cas12b) have been studied in detail, the distinct...
5.
Yan W, Chong S, Zhang H, Makarova K, Koonin E, Cheng D, et al.
Mol Cell
. 2018 Mar;
70(2):327-339.e5.
PMID: 29551514
Bacterial class 2 CRISPR-Cas systems utilize a single RNA-guided protein effector to mitigate viral infection. We aggregated genomic data from multiple sources and constructed an expanded database of predicted class...