Shanmugapriya Sothiselvam
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Explore the profile of Shanmugapriya Sothiselvam including associated specialties, affiliations and a list of published articles.
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7
Citations
517
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Recent Articles
1.
McGaw C, Garrity A, Munoz G, Haswell J, Sengupta S, Keston-Smith E, et al.
Nat Commun
. 2022 May;
13(1):2833.
PMID: 35595757
The CRISPR-Cas type V-I is a family of Cas12i-containing programmable nuclease systems guided by a short crRNA without requirement for a tracrRNA. Here we present an engineered Type V-I CRISPR...
2.
Beckert B, Leroy E, Sothiselvam S, Bock L, Svetlov M, Graf M, et al.
Nat Commun
. 2021 Jul;
12(1):4466.
PMID: 34294725
Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these antibiotics are known to...
3.
Torres M, Sothiselvam S, Lu T, de la Fuente-Nunez C
J Mol Biol
. 2019 Jan;
431(18):3547-3567.
PMID: 30611750
The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel anti-infective therapies. Antimicrobial peptides (AMPs) represent promising alternatives to...
4.
Yan W, Hunnewell P, Alfonse L, Carte J, Keston-Smith E, Sothiselvam S, et al.
Science
. 2018 Dec;
363(6422):88-91.
PMID: 30523077
Type V CRISPR-Cas systems are distinguished by a single RNA-guided RuvC domain-containing effector, Cas12. Although effectors of subtypes V-A (Cas12a) and V-B (Cas12b) have been studied in detail, the distinct...
5.
Sothiselvam S, Neuner S, Rigger L, Klepacki D, Micura R, Vazquez-Laslop N, et al.
Cell Rep
. 2016 Aug;
16(7):1789-99.
PMID: 27498876
Macrolide antibiotic binding to the ribosome inhibits catalysis of peptide bond formation between specific donor and acceptor substrates. Why particular reactions are problematic for the macrolide-bound ribosome remains unclear. Using...
6.
Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson G, et al.
Proc Natl Acad Sci U S A
. 2014 Jun;
111(27):9804-9.
PMID: 24961372
Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome....
7.
Gupta P, Sothiselvam S, Vazquez-Laslop N, Mankin A
Nat Commun
. 2013 Jun;
4:1984.
PMID: 23749080
A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are...