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David P Bazett-Jones

Explore the profile of David P Bazett-Jones including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Kalkat M, Chan P, Wasylishen A, Srikumar T, Kim S, Ponzielli R, et al.
PLoS One . 2014 Dec; 9(12):e115337. PMID: 25522242
The c-MYC transcription factor is a master regulator of many cellular processes and deregulation of this oncogene has been linked to more than 50% of all cancers. This deregulation can...
12.
Chen B, Anchel D, Gong Z, Cotton R, Li R, Sun Y, et al.
Small . 2014 May; 10(16):3267-74. PMID: 24799430
The relative positioning of gene loci within a mammalian nucleus is non-random and plays a role in gene regulation. Some sub-nuclear structures may represent "hubs" that bring specific genetic loci...
13.
Even-Faitelson L, Fussner E, Li R, Strauss M, Bazett-Jones D
Methods Mol Biol . 2013 Aug; 1042:181-95. PMID: 23980008
The eukaryotic genome is packaged within the nucleus as poly-nucleosome 10 nm chromatin fibres. The nucleosome core particle, the fundamental chromatin subunit, consists of a DNA molecule wrapped around a...
14.
Visvanathan A, Ahmed K, Even-Faitelson L, Lleres D, Bazett-Jones D, Lamond A
PLoS One . 2013 Jul; 8(6):e67689. PMID: 23840764
The organisation of the large volume of mammalian genomic DNA within cell nuclei requires mechanisms to regulate chromatin compaction involving the reversible formation of higher order structures. The compaction state...
15.
Comartin D, Gupta G, Fussner E, Coyaud E, Hasegan M, Archinti M, et al.
Curr Biol . 2013 Jul; 23(14):1360-6. PMID: 23810536
Centrosomes organize microtubule (MT) arrays and are comprised of centrioles surrounded by ordered pericentriolar proteins. Centrioles are barrel-shaped structures composed of MTs, and as basal bodies they template the formation...
16.
Ching R, Ahmed K, Boutros P, Penn L, Bazett-Jones D
J Cell Biol . 2013 Apr; 201(2):325-35. PMID: 23589495
Important insights into nuclear function would arise if gene loci physically interacting with particular subnuclear domains could be readily identified. Immunofluorescence microscopy combined with fluorescence in situ hybridization (immuno-FISH), the...
17.
Fussner E, Strauss M, Djuric U, Li R, Ahmed K, Hart M, et al.
EMBO Rep . 2012 Sep; 13(11):992-6. PMID: 22986547
The mammalian genome is compacted to fit within the confines of the cell nucleus. DNA is wrapped around nucleosomes, forming the classic "beads-on-a-string" 10-nm chromatin fibre. Ten-nanometre chromatin fibres are...
18.
Chandra T, Kirschner K, Thuret J, Pope B, Ryba T, Newman S, et al.
Mol Cell . 2012 Jul; 47(2):203-14. PMID: 22795131
The expansion of repressive epigenetic marks has been implicated in heterochromatin formation during embryonic development, but the general applicability of this mechanism is unclear. Here we show that nuclear rearrangement...
19.
Rapkin L, Anchel D, Li R, Bazett-Jones D
Micron . 2011 Dec; 43(2-3):150-8. PMID: 22172345
The microscope has been indispensable to the last century of chromatin structure research. Microscopy techniques have revealed that the three-dimensional location of chromatin is not random but represents a further...
20.
Fussner E, Djuric U, Strauss M, Hotta A, Perez-Iratxeta C, Lanner F, et al.
EMBO J . 2011 Apr; 30(9):1778-89. PMID: 21468033
Induced pluripotent stem (iPS) cell reprogramming is a gradual epigenetic process that reactivates the pluripotent transcriptional network by erasing and establishing repressive epigenetic marks. In contrast to loci-specific epigenetic changes,...