James Ellis
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Explore the profile of James Ellis including associated specialties, affiliations and a list of published articles.
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113
Citations
4095
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Recent Articles
1.
Ellis J, Gilworth G, Morgan T, Harris K, King N, White P
Int J Chron Obstruct Pulmon Dis
. 2025 Mar;
20:533-538.
PMID: 40060921
Background: Recent evidence suggests that remote pulmonary rehabilitation (PR) meeting international criteria may be as effective as traditional in-person PR. During social distancing associated with COVID-19, in-person PR services were...
2.
3.
Gordillo-Sampedro S, Antounians L, Wei W, Mufteev M, Lendemeijer B, Kushner S, et al.
Mol Cell Neurosci
. 2024 Apr;
129:103933.
PMID: 38663691
Astrocytes are in constant communication with neurons during the establishment and maturation of functional networks in the developing brain. Astrocytes release extracellular vesicles (EVs) containing microRNA (miRNA) cargo that regulates...
4.
Kinnear C, Said A, Meng G, Zhao Y, Wang E, Rafatian N, et al.
Cell Rep Med
. 2024 Apr;
5(5):101520.
PMID: 38642550
Pathogenic variants in MYH7 and MYBPC3 account for the majority of hypertrophic cardiomyopathy (HCM). Targeted drugs like myosin ATPase inhibitors have not been evaluated in children. We generate patient and...
5.
Pradeepan K, McCready F, Wei W, Khaki M, Zhang W, Salter M, et al.
Biol Psychiatry Glob Open Sci
. 2024 Feb;
4(2):100290.
PMID: 38420187
Background: Mutations in predominantly cause Rett syndrome and can be modeled in vitro using human stem cell-derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures....
6.
Hua M, Williams L, Burns K, Liu S, Ellis J, Innes A, et al.
Stem Cell Res
. 2024 Feb;
76:103344.
PMID: 38364506
The identification of neurodevelopmental defects in a patient harboring a heterozygous de novo missense variant (NM_006561.4, c.1517G > A, p.Arg506His) within the CELF2 gene. Here, we describe the establishment of...
7.
Oliveros W, Delfosse K, Lato D, Kiriakopulos K, Mokhtaridoost M, Said A, et al.
Cell Genom
. 2023 Jul;
3(7):100330.
PMID: 37492106
High blood pressure (BP) is the major risk factor for cardiovascular disease. Genome-wide association studies have identified genetic variants for BP, but functional insights into causality and related molecular mechanisms...
8.
Dave B, Chen X, McCready F, Charton C, Morley R, Tailor J, et al.
Development
. 2023 Jun;
150(13).
PMID: 37381820
Cerebellar granule neurons (CGNs) are the most abundant neurons in the human brain. Dysregulation of their development underlies movement disorders and medulloblastomas. It is suspected that these disorders arise in...
9.
Rodrigues D, Mufteev M, Yuki K, Narula A, Wei W, Piekna A, et al.
Nat Commun
. 2023 Apr;
14(1):1896.
PMID: 37019888
Transcriptional changes in Rett syndrome (RTT) are assumed to directly correlate with steady-state mRNA levels, but limited evidence in mice suggests that changes in transcription can be compensated by post-transcriptional...
10.
Mufteev M, Rodrigues D, Yuki K, Narula A, Wei W, Piekna A, et al.
bioRxiv
. 2023 Mar;
PMID: 36909614
The contribution of mRNA half-life is commonly overlooked when examining changes in mRNA abundance during development. mRNA levels of some genes are regulated by transcription rate only, but others may...