David N Sheppard
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Explore the profile of David N Sheppard including associated specialties, affiliations and a list of published articles.
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80
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1844
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Recent Articles
11.
Saint-Criq V, Wang Y, Delpiano L, Lin J, Sheppard D, Gray M
J Cyst Fibros
. 2021 May;
20(5):843-850.
PMID: 34020896
Background: The clinical response to cystic fibrosis transmembrane conductance regulator (CFTR) modulators varies between people with cystic fibrosis (CF) of the same genotype, in part through the action of solute...
12.
Rodrat M, Jantarajit W, Ng D, Harvey B, Liu J, Wilkinson W, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Sep;
319(6):L997-L1009.
PMID: 32936026
The gasotransmitter carbon monoxide (CO) regulates fluid and electrolyte movements across epithelial tissues. However, its action on anion channels is incompletely understood. Here, we investigate the direct action of CO...
13.
Li H, Valkenier H, Thorne A, Dias C, Cooper J, Kieffer M, et al.
Chem Sci
. 2020 Feb;
10(42):9663-9672.
PMID: 32055336
Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including...
14.
Jantarajit W, Wongdee K, Lertsuwan K, Teerapornpuntakit J, Aeimlapa R, Thongbunchoo J, et al.
Biochem Biophys Res Commun
. 2020 Jan;
523(3):816-821.
PMID: 31954520
Parathyroid hormone (PTH) enhances cystic fibrosis transmembrane conductance regulator (CFTR)-mediated anion secretion by the human intestinal epithelial cell line Caco-2. With the patch-clamp and Ussing chamber techniques, we investigated how...
15.
Bose S, Krainer G, Ng D, Schenkel M, Shishido H, Yoon J, et al.
J Cyst Fibros
. 2020 Jan;
19 Suppl 1:S25-S32.
PMID: 31902693
The treatment of cystic fibrosis (CF) has been transformed by orally-bioavailable small molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), which restore function to CF mutants. However, CFTR...
16.
Hinzpeter A, Sermet-Gaudelus I, Sheppard D
J Physiol
. 2019 Dec;
598(3):429-430.
PMID: 31869855
No abstract available.
17.
Kleizen B, Hunt J, Callebaut I, Hwang T, Sermet-Gaudelus I, Hafkemeyer S, et al.
J Cyst Fibros
. 2019 Nov;
19 Suppl 1:S19-S24.
PMID: 31759907
Structural biology and functional studies are a powerful combination to elucidate fundamental knowledge about the cystic fibrosis transmembrane conductance regulator (CFTR). Here, we discuss the latest findings, including how clinically-approved...
18.
Higham J, Sahu G, Wazen R, Colarusso P, Gregorie A, Harvey B, et al.
Mol Pharmacol
. 2019 May;
96(1):115-126.
PMID: 31048549
Three small conductance calcium-activated potassium channel (SK) subunits have been cloned and found to preferentially form heteromeric channels when expressed in a heterologous expression system. The original cloning of the...
19.
Bose S, Bijvelds M, Wang Y, Liu J, Cai Z, Bot A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2019 Apr;
317(1):L71-L86.
PMID: 30969810
Cross-species comparative studies have highlighted differences between human and mouse cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial Cl channel defective in cystic fibrosis (CF). Here, we compare the impact...
20.
Spooner M, Li H, Marques I, Costa P, Wu X, Howe E, et al.
Chem Sci
. 2019 Mar;
10(7):1976-1985.
PMID: 30881627
A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in...