David M Tarlinton
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Explore the profile of David M Tarlinton including associated specialties, affiliations and a list of published articles.
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115
Citations
6514
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Recent Articles
1.
Dvorscek A, McKenzie C, Staheli V, Ding Z, White J, Fabb S, et al.
Immunity
. 2024 Sep;
57(10):2433-2452.e7.
PMID: 39305904
Existing antibodies (Abs) have varied effects on humoral immunity during subsequent infections. Here, we leveraged in vivo systems that allow precise control of antigen-specific Abs and B cells to examine...
2.
Ding Z, Hagan M, Yan F, Schroer N, Polmear J, Good-Jacobson K, et al.
J Exp Med
. 2024 Jun;
221(8).
PMID: 38842525
The proliferation marker Ki67 has been attributed critical functions in maintaining mitotic chromosome morphology and heterochromatin organization during the cell cycle, indicating a potential role in developmental processes requiring rigid...
3.
Robinson M, Tarlinton D
Immunity
. 2024 Mar;
57(3):408-410.
PMID: 38479357
Plasma cells (PCs) rely on external survival cues for persistence, which limits the size of the PC pool. How, then, are new specificities incorporated into a saturated system? In this...
4.
Robinson M, Ding Z, Dowling M, Hill D, Webster R, McKenzie C, et al.
Immunity
. 2023 May;
56(7):1596-1612.e4.
PMID: 37164016
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and persistence using a genetic reporter to time-stamp ASCs....
5.
Tarlinton D, Ding Z, Tellier J, Nutt S
Curr Opin Immunol
. 2023 Mar;
81:102297.
PMID: 36889029
Plasma cells (PCs) are essential for the quality and longevity of protective immunity. The canonical humoral response to vaccination involves induction of germinal centers in lymph nodes followed by maintenance...
6.
Wade-Vallance A, Yang Z, Libang J, Robinson M, Tarlinton D, Allen C
J Exp Med
. 2023 Mar;
220(4).
PMID: 36880536
The proper regulation of IgE production safeguards against allergic disease, highlighting the importance of mechanisms that restrict IgE plasma cell (PC) survival. IgE PCs have unusually high surface B cell...
7.
Ding Z, Quast I, Yan F, Liao Y, Pitt C, O-Donnell K, et al.
Immunol Cell Biol
. 2022 Aug;
100(9):705-717.
PMID: 35916066
Aberrant expression of the proto-oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell-specific immunoglobulin heavy chain μ intron...
8.
Quast I, Dvorscek A, Pattaroni C, Steiner T, McKenzie C, Pitt C, et al.
Immunity
. 2022 Jul;
55(8):1414-1430.e5.
PMID: 35896116
Germinal centers (GCs), transient structures within B cell follicles and central to affinity maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell-derived cytokine, is...
9.
Dvorscek A, McKenzie C, Robinson M, Ding Z, Pitt C, ODonnell K, et al.
EMBO Rep
. 2022 Jul;
23(9):e54677.
PMID: 35801309
The proliferation and differentiation of antigen-specific B cells, including the generation of germinal centers (GC), are prerequisites for long-lasting, antibody-mediated immune protection. Affinity for antigen determines B cell recruitment, proliferation,...
10.
Zotos D, Quast I, Li-Wai-Suen C, McKenzie C, Robinson M, Kan A, et al.
Nat Commun
. 2021 Dec;
12(1):7160.
PMID: 34887406
Humoral immune responses require germinal centres (GC) for antibody affinity maturation. Within GC, B cell proliferation and mutation are segregated from affinity-based positive selection in the dark zone (DZ) and...