David M Bryant
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Explore the profile of David M Bryant including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Roman-Fernandez A, Sandilands E, Bryant D
Methods Mol Biol
. 2022 Feb;
2438:439-454.
PMID: 35147956
The three-dimensional culture of epithelial cells allows the characterization of processes required for collective epithelial polarization, such as formation of an epithelial lumen. Madin-Darby Canine Kidney (MDCK) cells have been...
12.
Naszai M, Bellec K, Yu Y, Roman-Fernandez A, Sandilands E, Johansson J, et al.
Elife
. 2021 Jun;
10.
PMID: 34096503
RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they...
13.
Nacke M, Sandilands E, Nikolatou K, Roman-Fernandez A, Mason S, Patel R, et al.
Nat Commun
. 2021 Mar;
12(1):1623.
PMID: 33712589
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive cellular responses occur is unclear. Here, we report development of 3-Dimensional culture analyses to separately...
14.
Millar R, Kilbey A, Remak S, Severson T, Dhayade S, Sandilands E, et al.
Mol Oncol
. 2020 Jun;
14(8):1868-1880.
PMID: 32484599
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has contributed to...
15.
Kugeratski F, Atkinson S, Neilson L, Lilla S, Knight J, Serneels J, et al.
Sci Signal
. 2019 Feb;
12(567).
PMID: 30723174
Intratumoral hypoxia causes the formation of dysfunctional blood vessels, which contribute to tumor metastasis and reduce the efficacy of therapeutic treatments. Blood vessels are embedded in the tumor stroma of...
16.
Roman-Fernandez A, Roignot J, Sandilands E, Nacke M, Mansour M, McGarry L, et al.
Nat Commun
. 2018 Nov;
9(1):5041.
PMID: 30487552
Apical-basal polarization is essential for epithelial tissue formation, segregating cortical domains to perform distinct physiological functions. Cortical lipid asymmetry has emerged as a determinant of cell polarization. We report a...
17.
Hewit K, Sandilands E, Martinez R, James D, Leung H, Bryant D, et al.
Cell Death Dis
. 2018 Oct;
9(11):1069.
PMID: 30341281
Based on a molecular classification of prostate cancer using gene expression pathway signatures, we derived a set of 48 genes in critical pathways that significantly predicts clinical outcome in all...
18.
Fort L, Batista J, Thomason P, Spence H, Whitelaw J, Tweedy L, et al.
Nat Cell Biol
. 2018 Sep;
20(10):1159-1171.
PMID: 30250061
Actin-based protrusions are reinforced through positive feedback, but it is unclear what restricts their size, or limits positive signals when they retract or split. We identify an evolutionarily conserved regulator...
19.
Stehbens S, Ju R, Adams M, Perry S, Haass N, Bryant D, et al.
J Cell Sci
. 2018 Jul;
131(15).
PMID: 30002137
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that control a diverse range of biological processes during development and in adult tissues. We recently reported that...
20.
Datta A, Sandilands E, Mostov K, Bryant D
Cell Signal
. 2017 Sep;
40:91-98.
PMID: 28888686
The formation of lumens in epithelial tissues requires apical-basal polarization of cells, and the co-ordination of this individual polarity collectively around a contiguous lumen. Signals from the Extracellular Matrix (ECM)...