Jason T Snyder
Overview
Explore the profile of Jason T Snyder including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
537
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Recent Articles
1.
Johnston C, Afshar K, Snyder J, Tall G, Gonczy P, Siderovski D, et al.
J Biol Chem
. 2008 Jun;
283(31):21550-8.
PMID: 18519563
Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (Galpha(o)) and GPA-16 (Galpha(i)) are involved in generating...
2.
Cheever M, Snyder J, Gershburg S, Siderovski D, Harden T, Sondek J
Nat Struct Mol Biol
. 2008 Jan;
15(2):155-62.
PMID: 18204463
Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs)....
3.
Yohe M, Rossman K, Gardner O, Karnoub A, Snyder J, Gershburg S, et al.
J Biol Chem
. 2007 Mar;
282(18):13813-23.
PMID: 17337446
Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catalyze exchange. Because...
4.
Jezyk M, Snyder J, Gershberg S, Worthylake D, Harden T, Sondek J
Nat Struct Mol Biol
. 2006 Nov;
13(12):1135-40.
PMID: 17115053
Although diverse signaling cascades require the coordinated regulation of heterotrimeric G proteins and small GTPases, these connections remain poorly understood. We present the crystal structure of the GTPase Rac1 bound...
5.
Snyder J, Jezyk M, Gershburg S, Harden T, Sondek J
Methods Enzymol
. 2006 Feb;
406:272-80.
PMID: 16472664
Small GTPases function as molecular switches, which transduce cellular signals from upstream regulators to downstream effectors in a guanine nucleotide-dependent manner. Direct binding partners of small GTPases fall into four...
6.
Seifert J, Snyder J, Sondek J, Harden T
Methods Enzymol
. 2006 Feb;
406:260-71.
PMID: 16472663
Phospholipase C-epsilon (PLC-epsilon) was shown recently to be a downstream effector of Rho GTPases, and we have used an in vitro phospholipid vesicle reconstitution system with purified proteins to show...
7.
Smith W, Hamel B, Yohe M, Sondek J, Cerione R, Snyder J
Biochemistry
. 2005 Oct;
44(40):13282-90.
PMID: 16201754
The Rho family GTPase Cdc42 functions as a molecular switch and controls many fundamental cellular processes such as cytoskeletal regulation, cell polarity, and vesicular trafficking. Guanine nucleotide exchange factors of...
8.
Seifert J, Wing M, Snyder J, Gershburg S, Sondek J, Harden T
J Biol Chem
. 2004 Aug;
279(46):47992-7.
PMID: 15322077
Phospholipase C-epsilon (PLC-epsilon) is a recently identified PLC isoform activated by subunits of heterotrimeric G proteins (Galpha(12), Galpha(13), and Gbetagamma) as well as by the low molecular weight GTPases, Rho...
9.
Wing M, Snyder J, Sondek J, Harden T
J Biol Chem
. 2003 Aug;
278(42):41253-8.
PMID: 12900402
Unique among the phospholipase C isozymes, the recently identified phospholipase C-epsilon (PLC-epsilon) contains an amino-terminal CDC25 domain capable of catalyzing nucleotide exchange on Ras family GTPases as well as a...
10.
Snyder J, Singer A, Wing M, Harden T, Sondek J
J Biol Chem
. 2003 Mar;
278(23):21099-104.
PMID: 12657629
Increasing evidence links the activation of Rho family GTPases to the stimulation of lipid hydrolysis catalyzed by phospholipase C (PLC)-beta isozymes. To better define this relationship, members of a library...