David J Picketts
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Explore the profile of David J Picketts including associated specialties, affiliations and a list of published articles.
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1322
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Recent Articles
1.
Levesque M, Picketts D
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40004235
Ribosome biogenesis is one of the most fundamental and energetically demanding cellular processes. In humans, the ribosomal DNA (rDNA) repeats span a large region of DNA and comprise 200 to...
2.
Clemot-Dupont S, Lourenco Fernandes J, Larrigan S, Sun X, Medisetti S, Stanley R, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(3):e2405981122.
PMID: 39808658
Although chromatin remodelers are among the most important risk genes associated with neurodevelopmental disorders (NDDs), the roles of these complexes during brain development are in many cases unclear. Here, we...
3.
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, et al.
Cancer Res
. 2024 Nov;
85(3):424-441.
PMID: 39531507
c-MYC is an important driver of high-risk neuroblastoma. A lack of c-MYC-driven genetically engineered mouse models (GEMM) has hampered the ability to better understand mechanisms of neuroblastoma oncogenesis and to...
4.
Loan A, Awaja N, Lui M, Syal C, Sun Y, Sarma S, et al.
Theranostics
. 2024 Oct;
14(16):6110-6137.
PMID: 39431007
Brain pericytes can acquire multipotency to produce multi-lineage cells following injury. However, pericytes are a heterogenous population and it remains unknown whether there are different potencies from different subsets of...
5.
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, et al.
bioRxiv
. 2024 Apr;
PMID: 38559042
The MYC proto-oncogenes (c-MYC, , ) are among the most deregulated oncogenic drivers in human malignancies including high-risk neuroblastoma, 50% of which are -amplified. Genetically engineered mouse models (GEMMs) based...
6.
Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, et al.
EMBO Rep
. 2024 Mar;
25(3):1256-1281.
PMID: 38429579
The plant homeodomain zinc-finger protein, PHF6, is a transcriptional regulator, and PHF6 germline mutations cause the X-linked intellectual disability (XLID) Börjeson-Forssman-Lehmann syndrome (BFLS). The mechanisms by which PHF6 regulates transcription...
7.
Tillotson R, Yan K, Ruston J, DeYoung T, Cordova A, Turcotte-Cardin V, et al.
Hum Mol Genet
. 2023 May;
32(15):2485-2501.
PMID: 37171606
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but...
8.
Abdallah A, Cardona H, Gadd S, Brat D, Powla P, Alruwalli W, et al.
Neurooncol Adv
. 2023 Feb;
5(1):vdad003.
PMID: 36845293
Background: Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in , the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine...
9.
Gillis H, Kalinina A, Xue Y, Yan K, Turcotte-Cardin V, Todd M, et al.
Exp Neurol
. 2023 Jan;
362:114326.
PMID: 36682400
The high incidence of ischemic stroke worldwide and poor efficacy of neuroprotective drugs has increased the need for novel therapies in stroke recovery. Transcription of the neurosecretory protein VGF (non-acronym)...
10.
Zapata G, Yan K, Picketts D
Hum Mol Genet
. 2022 May;
31(20):3405-3421.
PMID: 35604347
Heterozygous variants in bromodomain and plant homeodomain containing transcription factor (BPTF) cause the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL) syndrome (MIM#617755) characterized by intellectual disability, speech...