Keqin Yan
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Explore the profile of Keqin Yan including associated specialties, affiliations and a list of published articles.
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38
Citations
383
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Recent Articles
1.
Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, et al.
EMBO Rep
. 2024 Mar;
25(3):1256-1281.
PMID: 38429579
The plant homeodomain zinc-finger protein, PHF6, is a transcriptional regulator, and PHF6 germline mutations cause the X-linked intellectual disability (XLID) Börjeson-Forssman-Lehmann syndrome (BFLS). The mechanisms by which PHF6 regulates transcription...
2.
Picketts D, Mirzaa G, Yan K, Relator R, Timpano S, Yalcin B, et al.
Res Sq
. 2023 Oct;
PMID: 37841849
Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause of neurodevelopmental disorders (NDDs). The NURF complex consists of BPTF and either the SNF2H () or SNF2L () ISWI-chromatin...
3.
Tillotson R, Yan K, Ruston J, DeYoung T, Cordova A, Turcotte-Cardin V, et al.
Hum Mol Genet
. 2023 May;
32(15):2485-2501.
PMID: 37171606
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but...
4.
Gillis H, Kalinina A, Xue Y, Yan K, Turcotte-Cardin V, Todd M, et al.
Exp Neurol
. 2023 Jan;
362:114326.
PMID: 36682400
The high incidence of ischemic stroke worldwide and poor efficacy of neuroprotective drugs has increased the need for novel therapies in stroke recovery. Transcription of the neurosecretory protein VGF (non-acronym)...
5.
Zapata G, Yan K, Picketts D
Hum Mol Genet
. 2022 May;
31(20):3405-3421.
PMID: 35604347
Heterozygous variants in bromodomain and plant homeodomain containing transcription factor (BPTF) cause the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL) syndrome (MIM#617755) characterized by intellectual disability, speech...
6.
Feng D, Lin J, Wang W, Yan K, Liang H, Liang J, et al.
Pathol Oncol Res
. 2021 Jul;
27:609620.
PMID: 34257574
Piwil2 reprograms HPV-infected reserve cells in the cervix into tumor-initiated cells (TICs) and upregulates Wnt3a expression sequentially, which leads to cervical intraepithelial neoplasia (CIN) and ultimately squamous cell carcinoma (SCC)....
7.
Ahmed R, Sarwar S, Hu J, Cardin V, Qiu L, Zapata G, et al.
Hum Mol Genet
. 2021 Mar;
30(7):575-594.
PMID: 33772537
The PHF6 mutation c.1024C > T; p.R342X, is a recurrent cause of Börjeson-Forssman-Lehmann Syndrome (BFLS), a neurodevelopmental disorder characterized by moderate-severe intellectual disability, truncal obesity, gynecomastia, hypogonadism, long tapering fingers...
8.
Lagali P, Zhao B, Yan K, Baker A, Coupland S, Tsilfidis C, et al.
Neuroscience
. 2020 Nov;
452:169-180.
PMID: 33197500
Mutation of the α-thalassemia/mental retardation syndrome X-linked protein, ATRX, causes intellectual disability and is associated with pleiotropic defects including ophthalmological abnormalities. We have previously demonstrated that Atrx deficiency in the...
9.
Feng D, Yan K, Liang H, Liang J, Wang W, Yu H, et al.
Neoplasia
. 2020 Nov;
23(1):1-11.
PMID: 33190089
Our previous work demonstrated that Piwil2 reactivated by the human papillomavirus oncoproteins E6 and E7 may reprogram somatic cells into tumor-initiating cells (TICs), which contribute to cervical neoplasia lesions. Maintaining...
10.
Correction to: C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Young K, Yan K, Picketts D
J Neuroinflammation
. 2020 Jan;
17(1):32.
PMID: 31973732
Following publication of the original article, the authors noticed missing labels in Fig. 1a.