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David J Cousins

Explore the profile of David J Cousins including associated specialties, affiliations and a list of published articles. Areas
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Articles 36
Citations 1338
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Recent Articles
1.
Easton F, Cousins D
Am J Respir Crit Care Med . 2023 Oct; 208(10):1015-1016. PMID: 37792423
No abstract available.
2.
Brightling C, Nair P, Cousins D, Louis R, Singh D
N Engl J Med . 2021 Oct; 385(18):1669-1679. PMID: 34706172
Background: Interleukin-23 has been implicated in airway inflammation that is mediated by type 2 and type 17 cytokines. Whether targeting interleukin-23 in the treatment of asthma improves disease control and...
3.
Dhariwal J, Cameron A, Wong E, Paulsen M, Trujillo-Torralbo M, Del Rosario A, et al.
Am J Respir Crit Care Med . 2021 Sep; 204(11):1259-1273. PMID: 34469272
Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced...
4.
Hardman C, Chen Y, Salimi M, Nahler J, Corridoni D, Jagielowicz M, et al.
Sci Immunol . 2021 May; 6(59). PMID: 34021026
Cutaneous group 2 innate lymphoid cells (ILC2) are spatially and epigenetically poised to respond to barrier compromise and associated immunological threats. ILC2, lacking rearranged antigen-specific receptors, are primarily activated by...
5.
McErlean P, Kelly A, Dhariwal J, Kirtland M, Watson J, Ranz I, et al.
Front Genet . 2020 Dec; 11:585746. PMID: 33362848
Background: Asthma is a chronic airway disease driven by complex genetic-environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood. Methods: We piloted...
6.
Povoleri G, Nova-Lamperti E, Scotta C, Fanelli G, Chen Y, Becker P, et al.
Nat Immunol . 2018 Nov; 19(12):1403-1414. PMID: 30397350
Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161 regulatory T (T) cells as a...
7.
Weston C, Rana B, Cousins D
J Allergy Clin Immunol . 2018 Sep; 143(1):410-413.e9. PMID: 30205185
No abstract available.
8.
Pfeffer P, Lu H, Mann E, Chen Y, Ho T, Cousins D, et al.
PLoS One . 2018 Aug; 13(8):e0200040. PMID: 30157189
Background: Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma. Objectives: Mechanistic cell culture experiments were...
9.
Recaldin T, Hobson P, Mann E, Ramadani F, Cousins D, Lavender P, et al.
Mol Immunol . 2018 Aug; 101:419-428. PMID: 30081328
Class-switch recombination (CSR) is an essential B cell process that alters the isotype of antibody produced by the B cell, tailoring the immune response to the nature of the invading...
10.
Hardman C, Chen Y, Salimi M, Jarrett R, Johnson D, Jarvinen V, et al.
Sci Immunol . 2017 Dec; 2(18). PMID: 29273672
Group 2 innate lymphoid cells (ILC2) are effectors of barrier immunity, with roles in infection, wound healing, and allergy. A proportion of ILC2 express MHCII (major histocompatibility complex II) and...