David Hackes
Overview
Explore the profile of David Hackes including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
42
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0
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Recent Articles
1.
Muniesa-Vargas A, Davo-Martinez C, Ribeiro-Silva C, van der Woude M, Thijssen K, Haspels B, et al.
Nat Commun
. 2024 Apr;
15(1):3490.
PMID: 38664429
Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features...
2.
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy S, Janssens R, et al.
Nat Cell Biol
. 2024 Apr;
26(5):770-783.
PMID: 38600236
DNA-protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based processes such as replication, which is counteracted through proteolysis-mediated DPC...
3.
Slyskova J, Muniesa-Vargas A, Tojal Da Silva I, Drummond R, Park J, Hackes D, et al.
NAR Cancer
. 2023 Dec;
5(4):zcad057.
PMID: 38058548
The therapeutic efficacy of cisplatin and oxaliplatin depends on the balance between the DNA damage induction and the DNA damage response of tumor cells. Based on clinical evidence, oxaliplatin is...
4.
Theil A, Hackes D, Lans H
DNA Repair (Amst)
. 2023 Nov;
132:103568.
PMID: 37977600
The heterodecameric transcription factor IIH (TFIIH) functions in multiple cellular processes, foremost in nucleotide excision repair (NER) and transcription initiation by RNA polymerase II. TFIIH is essential for life and...
5.
Schwab K, Coronel L, Riege K, Sacramento E, Rahnis N, Hackes D, et al.
Cell Death Discov
. 2023 Mar;
9(1):80.
PMID: 36864036
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders....
6.
Coronel L, Hackes D, Schwab K, Riege K, Hoffmann S, Fischer M
Oncogene
. 2021 Dec;
41(7):1063-1069.
PMID: 34907345
In recent years the tumor suppressor p53 has been increasingly recognized as a potent regulator of the cell metabolism and for its ability to inhibit the critical pro-survival kinases AKT...
7.
Coronel L, Riege K, Schwab K, Forste S, Hackes D, Semerau L, et al.
Nucleic Acids Res
. 2021 Jul;
49(13):7437-7456.
PMID: 34197623
Despite its prominence, the mechanisms through which the tumor suppressor p53 regulates most genes remain unclear. Recently, the regulatory factor X 7 (RFX7) emerged as a suppressor of lymphoid neoplasms,...