David Gerhold
Overview
Explore the profile of David Gerhold including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
589
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Recent Articles
1.
Mannheimer J, Tawa G, Gerhold D, Braisted J, Sayers C, McEachron T, et al.
Commun Biol
. 2023 Aug;
6(1):856.
PMID: 37591946
Canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma. Here we show in one of the largest clinically annotated canine osteosarcoma transcriptional datasets that two previously reported,...
2.
Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, et al.
Annu Rev Pharmacol Toxicol
. 2023 Jul;
64:191-209.
PMID: 37506331
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of...
3.
Tong Z, Kim H, El Touny L, Simeonov A, Gerhold D
Neurotox Res
. 2022 Aug;
40(5):1537-1538.
PMID: 36029455
No abstract available.
4.
Tong Z, Kim H, El Touny L, Simeonov A, Gerhold D
Neurotox Res
. 2022 Aug;
40(5):1526-1536.
PMID: 35922689
Ferroptosis is a necrotic cell death caused by lipid oxidation that may be responsible for neural degeneration in Parkinson's disease. We assessed whether three neuronal cell lines are sensitive to...
5.
Tawa G, Braisted J, Gerhold D, Grewal G, Mazcko C, Breen M, et al.
PLoS Comput Biol
. 2021 Sep;
17(9):e1009450.
PMID: 34570764
Understanding relationships between spontaneous cancer in companion (pet) canines and humans can facilitate biomarker and drug development in both species. Towards this end we developed an experimental-bioinformatic protocol that analyzes...
6.
Tong Z, Braisted J, Chu P, Gerhold D
Neurotox Res
. 2020 Sep;
38(4):967-978.
PMID: 32870474
Identification of toxicants that underlie neurological diseases is a neglected area awaiting a valid strategy to identify such toxicants. We sought biomarkers that respond to known neurotoxicants in LUHMES immortalized...
7.
Xia M, Huang R, Shi Q, Boyd W, Zhao J, Sun N, et al.
Environ Health Perspect
. 2018 Jul;
126(7):077010.
PMID: 30059008
Background: A central challenge in toxicity testing is the large number of chemicals in commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing toxicity testing from animal...
8.
Pamies D, Bal-Price A, Simeonov A, Tagle D, Allen D, Gerhold D, et al.
ALTEX
. 2016 Aug;
34(1):95-132.
PMID: 27554434
The first guidance on Good Cell Culture Practice (GCCP) dates back to 2005. This document expands this to include aspects of quality assurance for in vitro cell culture focusing on...
9.
Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening
Tong Z, Hogberg H, Kuo D, Sakamuru S, Xia M, Smirnova L, et al.
J Appl Toxicol
. 2016 May;
37(2):167-180.
PMID: 27143523
More than 75 000 man-made chemicals contaminate the environment; many of these have not been tested for toxicities. These chemicals demand quantitative high-throughput screening assays to assess them for causative...
10.
Kleensang A, Maertens A, Rosenberg M, Fitzpatrick S, Lamb J, Auerbach S, et al.
ALTEX
. 2013 Oct;
31(1):53-61.
PMID: 24127042
Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains...