David Gani
Overview
Explore the profile of David Gani including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
799
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Recent Articles
1.
de Felipe P, Luke G, Hughes L, Gani D, Halpin C, Ryan M
Trends Biotechnol
. 2005 Dec;
24(2):68-75.
PMID: 16380176
Many applications of genetic engineering require transformation with multiple (trans)genes, although to achieve these using conventional techniques can be challenging. The 2A oligopeptide is emerging as a highly effective new...
2.
Miller D, Surfraz M, Akhtar M, Gani D, Allemann R
Org Biomol Chem
. 2004 Feb;
2(5):671-88.
PMID: 14985807
Inositol monophosphatase is widely held to be the therapeutic target for inhibition by lithium ion in the treatment of bipolar disorder. In a continued effort to improve the bioavailability of...
3.
Bargota R, Akhtar M, Biggadike K, Gani D, Allemann R
Bioorg Med Chem Lett
. 2003 May;
13(10):1623-6.
PMID: 12729627
Substrate analogues based on the parent compounds paraoxon and phenyl acetate were tested on human serum paraoxonase (PON1) to explore the active site of the enzyme. Replacement of the nitro...
4.
Asuncion M, Blankenfeldt W, Barlow J, Gani D, Naismith J
J Biol Chem
. 2001 Dec;
277(10):8306-11.
PMID: 11748244
Methylaspartate ammonia-lyase (3-methylaspartase, MAL; EC ) catalyzes the reversible anti elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to give mesaconic acid. This reaction lies on the main catabolic pathway for glutamate...
5.
Donnelly M, Hughes L, Luke G, Mendoza H, Ten Dam E, Gani D, et al.
J Gen Virol
. 2001 Apr;
82(Pt 5):1027-1041.
PMID: 11297677
The 2A/2B cleavage of aphtho- and cardiovirus 2A polyproteins is mediated by their 2A proteins 'cleaving' at their own C termini. We have analysed this activity using artificial reporter polyprotein...
6.
Donnelly M, Luke G, Mehrotra A, Li X, Hughes L, Gani D, et al.
J Gen Virol
. 2001 Apr;
82(Pt 5):1013-1025.
PMID: 11297676
The 2A region of the aphthovirus foot-and-mouth disease virus (FMDV) polyprotein is only 18 aa long. A 'primary' intramolecular polyprotein processing event mediated by 2A occurs at its own C...