David G Schatz
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Explore the profile of David G Schatz including associated specialties, affiliations and a list of published articles.
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124
Citations
4645
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Recent Articles
1.
Wu L, Yadavalli A, Senigl F, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, et al.
Mol Cell
. 2025 Mar;
PMID: 40049160
Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation-induced deaminase (AID), a single-stranded DNA cytidine deaminase thought to engage its substrate...
2.
Senigl F, Soikkeli A, Prost S, Schatz D, Slavkova M, Hejnar J, et al.
Tumour Virus Res
. 2024 Nov;
18:200293.
PMID: 39490533
Simian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas. A related Merkel cell polyomavirus causes...
3.
Wu L, Yadavalli A, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, Simon M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386505
Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation induced deaminase (AID), a single-stranded DNA cytidine deaminase that is thought to...
4.
Naik A, Dauphars D, Corbett E, Simpson L, Schatz D, Krangel M
Sci Immunol
. 2024 Mar;
9(93):eadh5318.
PMID: 38489350
Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4CD8 double-negative (DN) to the CD4CD8 double-positive (DP) stage, but the physiological importance and mechanism of transcriptional up-regulation are...
5.
Senigl F, Soikkeli A, Prost S, Schatz D, Slavkova M, Hejnar J, et al.
bioRxiv
. 2024 Jan;
PMID: 38260396
Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in mesotheliomas, brain and bone tumors and lymphomas, but the...
6.
Martin E, Le Targa L, Tsakou-Ngouafo L, Fan T, Lin C, Xiao J, et al.
Mol Biol Evol
. 2023 Oct;
40(11).
PMID: 37850912
A series of "molecular domestication" events are thought to have converted an invertebrate RAG-like (RAGL) transposase into the RAG1-RAG2 (RAG) recombinase, a critical enzyme for adaptive immunity in jawed vertebrates....
7.
Martin E, Le Targa L, Tsakou-Ngouafo L, Fan T, Lin C, Xiao J, et al.
bioRxiv
. 2023 Aug;
PMID: 37645967
A series of "molecular domestication" events are thought to have converted an invertebrate RAG-like (RAGL) transposase into the RAG1-RAG2 (RAG) recombinase, a critical enzyme for adaptive immunity in jawed vertebrates....
8.
9.
Wu L, Shukla V, Yadavalli A, Dinesh R, Xu D, Rao A, et al.
Genes Dev
. 2022 Apr;
36(7-8):433-450.
PMID: 35450882
Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B cells when uracils created by the activation-induced deaminase are processed in a mutagenic manner by enzymes of the...
10.
Tarsalainen A, Maman Y, Meng F, Kylaniemi M, Soikkeli A, Budzynska P, et al.
J Immunol
. 2021 Dec;
208(1):143-154.
PMID: 34862258
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig...