David G Schatz
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Explore the profile of David G Schatz including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Liu C, Zhang Y, Liu C, Schatz D
Nat Rev Immunol
. 2021 Oct;
22(6):353-370.
PMID: 34675378
Adaptive immunity in jawed vertebrates relies on the assembly of antigen receptor genes by the recombination activating gene 1 (RAG1)-RAG2 (collectively RAG) recombinase in a reaction known as V(D)J recombination....
12.
Gan T, Wang Y, Liu Y, Schatz D, Hu J
Cell Rep
. 2021 Oct;
37(2):109824.
PMID: 34644584
RAG1 and RAG2 form a tetramer nuclease to initiate V(D)J recombination in developing T and B lymphocytes. The RAG1 protein evolves from a transposon ancestor and possesses nuclease activity that...
13.
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Beilinson H, Glynn R, Yadavalli A, Xiao J, Corbett E, Saribasak H, et al.
J Exp Med
. 2021 Aug;
218(10).
PMID: 34402853
Immunoglobulin and T cell receptor gene assembly depends on V(D)J recombination initiated by the RAG1-RAG2 recombinase. The RAG1 N-terminal region (NTR; aa 1-383) has been implicated in regulatory functions whose...
14.
Liu C, Shi W, Becker S, Schatz D, Liu B, Yang Y
Science
. 2021 Jul;
373(6559):1142-1146.
PMID: 34315827
Coronavirus 3′-to-5′ exoribonuclease (ExoN), residing in the nonstructural protein (nsp) 10–nsp14 complex, boosts replication fidelity by proofreading RNA synthesis and is critical for the virus life cycle. ExoN also recognizes...
15.
Chen C, Chen B, Wang Y, Curman P, Beilinson H, Brecht R, et al.
J Exp Med
. 2021 May;
218(8).
PMID: 34033676
A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca2+...
16.
Yang Y, Liu C, Zhou W, Shi W, Chen M, Zhang B, et al.
Nat Commun
. 2021 May;
12(1):2702.
PMID: 33976201
Bacterial RNA polymerase (RNAP) holoenzyme initiates transcription by recognizing the conserved -35 and -10 promoter elements that are optimally separated by a 17-bp spacer. The MerR family of transcriptional regulators...
17.
Zhang Y, Corbett E, Wu S, Schatz D
EMBO J
. 2020 Sep;
39(21):e105857.
PMID: 32945578
Jawed vertebrate adaptive immunity relies on the RAG1/RAG2 (RAG) recombinase, a domesticated transposase, for assembly of antigen receptor genes. Using an integration-activated form of RAG1 with methionine at residue 848...
18.
Weinmann A, Youngblood B, Smale S, Brink R, Schatz D, McHeyzer-Williams M
Trends Immunol
. 2020 Jun;
41(7):549-555.
PMID: 32507312
No abstract available.
19.
Kuhny M, Forbes L, Cakan E, Vega-Loza A, Kostiuk V, Dinesh R, et al.
J Clin Invest
. 2020 Jun;
130(8):4411-4422.
PMID: 32484799
Patients with common variable immunodeficiency associated with autoimmune cytopenia (CVID+AIC) generate few isotype-switched B cells with severely decreased frequencies of somatic hypermutations (SHMs), but their underlying molecular defects remain poorly...
20.