David G Lambright
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Explore the profile of David G Lambright including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Perica T, Mathy C, Xu J, Jang G, Zhang Y, Kaake R, et al.
Nature
. 2021 Oct;
599(7883):152-157.
PMID: 34646016
Molecular switch proteins whose cycling between states is controlled by opposing regulators are central to biological signal transduction. As switch proteins function within highly connected interaction networks, the fundamental question...
2.
Mishra A, Lambright D
Methods Mol Biol
. 2021 Aug;
2293:27-43.
PMID: 34453708
Measurement of intrinsic as well as GTPase-activating Protein (GAP) catalyzed GTP hydrolysis is central to understanding the molecular mechanism and function of GTPases in diverse cellular processes. For the Rab...
3.
Duan J, Lambright D
Structure
. 2021 Aug;
29(8):779-781.
PMID: 34358462
COPII vesicle biogenesis at the endoplasmic reticulum requires activation of the Sar1 GTPase, which recruits the COP II coat protein complex to drive membrane budding. In this issue of Structure,...
4.
Li J, Lambright D, Hsu V
Mol Biol Cell
. 2020 Oct;
31(25):2816-2825.
PMID: 33026967
The action of guanine nucleotide exchange factors (GEFs) on the ADP-ribosylation factor (ARF) family of small GTPases initiates intracellular transport pathways. This role requires ARF GEFs to be recruited from...
5.
Struck M, Pazour G, Lambright D
Structure
. 2020 Apr;
28(4):385-387.
PMID: 32268075
Some Rab GTPases, after activation by GDP to GTP exchange, are phosphorylated by the LRRK2 kinase implicated in Parkinson's disease. In the current issue of Structure, Waschbüsch et al. (2020)...
6.
Das S, Malaby A, Nawrotek A, Zhang W, Zeghouf M, Maslen S, et al.
Structure
. 2019 Oct;
27(12):1782-1797.e7.
PMID: 31601460
Membrane dynamic processes require Arf GTPase activation by guanine nucleotide exchange factors (GEFs) with a Sec7 domain. Cytohesin family Arf GEFs function in signaling and cell migration through Arf GTPase...
7.
Sztul E, Chen P, Casanova J, Cherfils J, Dacks J, Lambright D, et al.
Mol Biol Cell
. 2019 May;
30(11):1249-1271.
PMID: 31084567
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional...
8.
Duan J, Lambright D
Dev Cell
. 2019 Jan;
48(1):9-11.
PMID: 30620905
GEFs play a key role in activation and membrane targeting of Rab GTPases. In this issue of Developmental Cell, Thomas et al. (2018) demonstrate how two TRAPP complexes with a...
9.
Malaby A, Das S, Chakravarthy S, Irving T, Bilsel O, Lambright D
Structure
. 2017 Dec;
26(1):106-117.e6.
PMID: 29276036
Membrane dynamic processes including vesicle biogenesis depend on Arf guanosine triphosphatase (GTPase) activation by guanine nucleotide exchange factors (GEFs) containing a catalytic Sec7 domain and a membrane-targeting module such as...
10.
Das S, Lambright D
Curr Biol
. 2016 Oct;
26(20):R927-R929.
PMID: 27780062
Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition...