David C Rubinsztein
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Explore the profile of David C Rubinsztein including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Li H, Fletcher-Etherington A, Hunter L, Keshri S, Fielding C, Nightingale K, et al.
Cell Host Microbe
. 2024 Mar;
32(4):466-478.e11.
PMID: 38479395
Human cytomegalovirus (HCMV) is an important human pathogen that regulates host immunity and hijacks host compartments, including lysosomes, to assemble virions. We combined a quantitative proteomic analysis of HCMV infection...
12.
Zhu Y, Fujimaki M, Snape L, Lopez A, Fleming A, Rubinsztein D
Nat Cell Biol
. 2024 Mar;
26(4):542-551.
PMID: 38454050
β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45)...
13.
Chen X, Tsvetkov A, Shen H, Isidoro C, Ktistakis N, Linkermann A, et al.
Autophagy
. 2024 Mar;
20(6):1213-1246.
PMID: 38442890
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to....
14.
Wang H, Siow R, Schmauck-Medina T, Zhang J, Sandset P, Filshie C, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Jan;
79(4).
PMID: 38289789
Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related...
15.
Son S, Park S, Breusegem S, Larrieu D, Rubinsztein D
Nat Cell Biol
. 2024 Jan;
26(2):235-249.
PMID: 38267537
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that...
16.
Ryan L, Rubinsztein D
FEBS Lett
. 2023 Dec;
598(1):59-72.
PMID: 38101818
Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One...
17.
Puri C, Rubinsztein D
Autophagy
. 2023 Dec;
20(5):1189-1191.
PMID: 38095212
Autophagosomes are double-membraned vesicles that engulf cytoplasmic contents, which are ultimately degraded after autophagosome-lysosome fusion. The prevailing view, largely inferred from EM-based studies, was that mammalian autophagosomes evolved from disc-shaped...
18.
Takla M, Keshri S, Rubinsztein D
EMBO Rep
. 2023 Sep;
24(11):e57574.
PMID: 37728021
Transcription factor EB (TFEB) is a basic helix-loop-helix leucine zipper transcription factor that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro-autophagy. TFEB contributes to a wide...
19.
Puri C, Gratian M, Rubinsztein D
Dev Cell
. 2023 Sep;
58(23):2746-2760.e5.
PMID: 37683632
The sequence of morphological intermediates that leads to mammalian autophagosome formation and closure is a crucial yet poorly understood issue. Previous studies have shown that yeast autophagosomes evolve from cup-shaped...
20.
Festa B, Siddiqi F, Jimenez-Sanchez M, Rubinsztein D
Autophagy
. 2023 Jun;
20(4):949-951.
PMID: 37358357
In the prodromal phase of neurodegenerative diseases, microglia switch to an activated state resulting in increased secretion of pro-inflammatory factors. We reported that C - C chemokine ligand 3 (CCL3),...