David C Goldstone
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Explore the profile of David C Goldstone including associated specialties, affiliations and a list of published articles.
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50
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2270
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Recent Articles
1.
Xu S, Wang S, Zhou Y, Foley N, Sun L, Walsham L, et al.
J Med Chem
. 2024 Oct;
67(21):19057-19076.
PMID: 39418501
Based on our proposed "pseudosubstrate envelope" concept, 25 benzothiazole-bearing HIV capsid protein (CA) modulators were designed and synthesized under the guidance of free energy perturbation technology. The most potent compound,...
2.
Eade L, Sullivan M, Allison T, Goldstone D, Hartinger C
Chemistry
. 2024 Mar;
30(28):e202400268.
PMID: 38472116
Modern approaches in metallodrug research focus on compounds that bind protein targets rather than DNA. However, the identification of protein targets and binding sites is challenging. Using intact mass spectrometry...
3.
Long D, Eade L, Sullivan M, Dost K, Meier-Menches S, Goldstone D, et al.
J Cheminform
. 2024 Feb;
16(1):15.
PMID: 38321500
Mass spectrometry (MS) is an analytical technique for molecule identification that can be used for investigating protein-metal complex interactions. Once the MS data is collected, the mass spectra are usually...
4.
Xu S, Sun L, Barnett M, Zhang X, Ding D, Gattu A, et al.
J Med Chem
. 2023 Dec;
66(23):16303-16329.
PMID: 38054267
Optimization of compound 11L led to the identification of novel HIV capsid modulators, quinazolin-4-one-bearing phenylalanine derivatives, displaying potent antiviral activities against both HIV-1 and HIV-2. Notably, derivatives and showed significant...
5.
Lin B, Nair S, Fellner D, Nasef N, Singh H, Negron L, et al.
Foods
. 2023 Nov;
12(22).
PMID: 38002130
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka () nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as methotrexate, are used...
6.
Barnett M, Pinheiro J, Keown J, Biboy J, Gray J, Lucinescu I, et al.
PLoS Pathog
. 2023 Aug;
19(8):e1011563.
PMID: 37585473
Trichomonas vaginalis is a human protozoan parasite that causes trichomoniasis, a prevalent sexually transmitted infection. Trichomoniasis is accompanied by a shift to a dysbiotic vaginal microbiome that is depleted of...
7.
Sullivan M, Adams M, Riisom M, Herbert C, Tong K, Astin J, et al.
Dalton Trans
. 2023 Jan;
52(5):1388-1392.
PMID: 36637059
Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency,...
8.
Jaudal M, Mayo-Smith M, Poulet A, Whibley A, Peng Y, Zhang L, et al.
Plant J
. 2022 Sep;
112(4):1029-1050.
PMID: 36178149
Flowering of the reference legume Medicago truncatula is promoted by winter cold (vernalization) followed by long-day photoperiods (VLD) similar to winter annual Arabidopsis. However, Medicago lacks FLC and CO, key...
9.
Taka J, Sun Y, Goldstone D
Protein Sci
. 2022 Sep;
31(10):e4436.
PMID: 36173157
Transcription of endogenous retroviral elements are tightly regulated during development by members of the KRAB-containing zinc finger proteins (KRAB-ZFPs) and the co-repressor Trim28 (also known as Kap-1 or Tif1β). KRAB-ZFPs...
10.
Webby M, Herr N, Bulloch E, Schmitz M, Keown J, Goldstone D, et al.
Viruses
. 2021 Sep;
13(9).
PMID: 34578318
The paramyxoviral phosphoprotein (P protein) is the non-catalytic subunit of the viral RNA polymerase, and coordinates many of the molecular interactions required for RNA synthesis. All paramyxoviral P proteins oligomerize...