David C Goldstone
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Explore the profile of David C Goldstone including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Lee B, Sullivan M, Yano E, Tong K, Hanif M, Kawakubo-Yasukochi T, et al.
Inorg Chem
. 2021 Sep;
60(19):14636-14644.
PMID: 34528438
N-Heterocyclic carbene (NHC) ligands are widely investigated in medicinal inorganic chemistry. Here, we report the preparation and characterization of a series of half-sandwich [M(L)(NHC)Cl] (M = Ru, Os, Rh, Ir;...
12.
Sullivan M, Cziferszky M, Tolbatov I, Truong D, Mercadante D, Re N, et al.
Angew Chem Int Ed Engl
. 2021 Jul;
60(36):19928-19932.
PMID: 34196088
Metal complexes can be considered a "paradigm of promiscuity" when it comes to their interactions with proteins. They often form adducts with a variety of donor atoms in an unselective...
13.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
14.
Oliver M, Horne C, Shrestha S, Keown J, Liang L, Young S, et al.
Nat Commun
. 2021 Feb;
12(1):1002.
PMID: 33579933
The life cycle of Baculoviridae family insect viruses depends on the viral protein kinase, PK-1, to phosphorylate the regulatory protein, p6.9, to induce baculoviral genome release. Here, we report the...
15.
Mustards-Derived Terpyridine-Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination
Adams M, Sullivan M, Tong K, Goldstone D, Hanif M, Jamieson S, et al.
Inorg Chem
. 2021 Jan;
60(4):2414-2424.
PMID: 33497565
The development of bifunctional platinum complexes with the ability to interact with DNA different binding modes is of interest in anticancer metallodrug research. Therefore, we report platinum(II) terpyridine complexes to...
16.
Daubit I, Sullivan M, John M, Goldstone D, Hartinger C, Metzler-Nolte N
Inorg Chem
. 2020 Nov;
59(23):17191-17199.
PMID: 33180473
While most Rh-N-heterocyclic carbene (NHC) complexes currently investigated in anticancer research contain a Rh(III) metal center, an increasing amount of research is focusing on the cytotoxic activity and mode of...
17.
Keown J, Yang J, Black M, Goldstone D
Acta Crystallogr D Struct Biol
. 2020 Oct;
76(Pt 10):954-961.
PMID: 33021497
Members of the TRIM protein family have been shown to inhibit a range of viral infections. Recently, TRIM69 was identified as a potent inhibitor of Vesicular stomatitis Indiana virus infection,...
18.
Truong D, Sullivan M, Tong K, Steel T, Prause A, Lovett J, et al.
Inorg Chem
. 2020 Feb;
59(5):3281-3289.
PMID: 32073260
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with -heterocyclic carbene (NHC) ligands, some of which have been shown to inhibit the...
19.
Acton O, Grant T, Nicastro G, Ball N, Goldstone D, Robertson L, et al.
Nat Commun
. 2019 Dec;
10(1):5822.
PMID: 31862888
The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and...
20.
Sullivan M, Morrow S, Goldstone D, Hartinger C
Electrophoresis
. 2019 May;
40(18-19):2329-2335.
PMID: 31087392
Cisplatin and its second and third generation analogues are widely used in the treatment of cancer. To study their reactions with proteins, we present a method based on SDS-PAGE separation...