David B Shackelford
Overview
Explore the profile of David B Shackelford including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
45
Citations
6429
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Varuzhanyan G, Chen C, Freeland J, He T, Tran W, Song K, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2416882121.
PMID: 39589879
Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC)...
2.
Klingbeil K, Wilde B, Graham D, Lofftus S, McCaw T, Matulionis N, et al.
Cancers (Basel)
. 2024 Sep;
16(17.
PMID: 39272889
Background: mTORC1 activity is dependent on the presence of micronutrients, including Asparagine (Asn), to promote anabolic cell signaling in many cancers. We hypothesized that targeting Asn metabolism would inhibit tumor...
3.
Long Jr D, Chan M, Han M, Kamdar Z, Ma R, Tsai P, et al.
Cell Rep Med
. 2024 Aug;
5(9):101699.
PMID: 39208801
Fibrolamellar carcinoma (FLC) is a rare, lethal, early-onset liver cancer with a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging...
4.
Krieger M, Abrahamian M, He K, Atamdede S, Hakimjavadi H, Momcilovic M, et al.
Life Sci Alliance
. 2024 Jul;
7(9.
PMID: 38955468
In addition to mitochondrial DNA, mitochondrial double-stranded RNA (mtdsRNA) is exported from mitochondria. However, specific channels for RNA transport have not been demonstrated. Here, we begin to characterize channel candidates...
5.
Geroyska S, Mejia I, Chan A, Navarrete M, Pandey V, Kharpatin S, et al.
Cancer Res Commun
. 2024 Jul;
4(7):1815-1833.
PMID: 38949950
Significance: KRAS-mutant lung carcinomas with LKB1 and/or KEAP1 co-mutations have intrinsic therapeutic resistance. We show that these tumors are sensitive to NMT inhibitors, which slow tumor growth in vivo and...
6.
Hong A, Piva M, Liu S, Hugo W, Lomeli S, Zoete V, et al.
Cancer Discov
. 2024 Jul;
14(7):1357.
PMID: 38946326
No abstract available.
7.
Nadres B, Momcilovic M, Shackelford D, Lisberg A
J Thorac Oncol
. 2023 Jun;
18(7):847-850.
PMID: 37348993
No abstract available.
8.
Han M, Bushong E, Segawa M, Tiard A, Wong A, Brady M, et al.
Nature
. 2023 Mar;
615(7953):712-719.
PMID: 36922590
Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells. The mitochondria form highly organized networks, in which their outer and inner membrane structures define their bioenergetic...
9.
Murray C, Brady J, Han M, Cai H, Tsai M, Pierce S, et al.
Nat Commun
. 2022 Mar;
13(1):1090.
PMID: 35228570
LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the...
10.
Velez M, Tsai H, Shackelford D, Garon E, Lisberg A
Lung Cancer
. 2022 Jan;
166:253-254.
PMID: 35031176
No abstract available.