David B Savage
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Explore the profile of David B Savage including associated specialties, affiliations and a list of published articles.
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105
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6661
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Recent Articles
11.
Seyres D, Cabassi A, Lambourne J, Burden F, Farrow S, McKinney H, et al.
Clin Epigenetics
. 2022 Mar;
14(1):39.
PMID: 35279219
Background: This work is aimed at improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis by generating a multi-omic disease signature. Methods/results: We combined classic plasma biochemistry...
12.
Rowe E, Mimmack M, Barbosa A, Haider A, Isaac I, Ouberai M, et al.
J Biol Chem
. 2021 Dec;
298(1):101490.
PMID: 34942404
No abstract available.
13.
Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, et al.
J Clin Endocrinol Metab
. 2021 Dec;
107(4):1065-1077.
PMID: 34875679
Context: Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking predominantly noncoding variants...
14.
Huang-Doran I, Kinzer A, Jimenez-Linan M, Thackray K, Harris J, Adams C, et al.
J Clin Endocrinol Metab
. 2021 Apr;
106(8):2367-2383.
PMID: 33901270
Context: Insulin resistance (IR) is associated with polycystic ovaries and hyperandrogenism, but underpinning mechanisms are poorly understood and therapeutic options are limited. Objective: To characterize hyperandrogenemia and ovarian pathology in...
15.
Alvarez-Guaita A, Patel S, Lim K, Haider A, Dong L, Conway O, et al.
Cell Rep
. 2021 Mar;
34(10):108810.
PMID: 33691105
Adipogenin (Adig) is an adipocyte-enriched transmembrane protein. Its expression is induced during adipogenesis in rodent cells, and a recent genome-wide association study associated body mass index (BMI)-adjusted leptin levels with...
16.
Lim K, Haider A, Adams C, Sleigh A, Savage D
Physiol Rev
. 2020 Dec;
101(3):907-993.
PMID: 33356916
Lipodystrophies have been recognized since at least the nineteenth century and, despite their rarity, tended to attract considerable medical attention because of the severity and somewhat paradoxical nature of the...
17.
18.
Coll A, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, et al.
Nature
. 2020 Feb;
578(7796):E24.
PMID: 32051582
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
19.
von Schnurbein J, Adams C, Akinci B, Ceccarini G, DApice M, Gambineri A, et al.
Orphanet J Rare Dis
. 2020 Jan;
15(1):17.
PMID: 31941540
Background: Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because...
20.
Coll A, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, et al.
Nature
. 2019 Dec;
578(7795):444-448.
PMID: 31875646
Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk. More than 60% of this effect is attributable to the...