David B Jaffe
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Explore the profile of David B Jaffe including associated specialties, affiliations and a list of published articles.
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62
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21165
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Recent Articles
11.
Evaluation of DISCOVAR de novo using a mosquito sample for cost-effective short-read genome assembly
Love R, Weisenfeld N, Jaffe D, Besansky N, Neafsey D
BMC Genomics
. 2016 Mar;
17:187.
PMID: 26944054
Background: De novo reference assemblies that are affordable, practical to produce, and of sufficient quality for most downstream applications, remain an unattained goal for many taxa. Insects, which may yield...
12.
Sundt D, Gamper N, Jaffe D
J Neurophysiol
. 2015 Sep;
114(6):3140-53.
PMID: 26334005
Unmyelinated C-fibers are a major type of sensory neurons conveying pain information. Action potential conduction is regulated by the bifurcation (T-junction) of sensory neuron axons within the dorsal root ganglia...
13.
Wang B, Jaffe D, Brenner R
Front Physiol
. 2014 Oct;
5:382.
PMID: 25346692
While most large-conductance, calcium-, and voltage-activated potassium channels (BK or Maxi-K type) are blocked by the scorpion venom iberiotoxin, the so-called "type II" subtype has the property of toxin resistance....
14.
Weisenfeld N, Yin S, Sharpe T, Lau B, Hegarty R, Holmes L, et al.
Nat Genet
. 2014 Oct;
46(12):1350-5.
PMID: 25326702
Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and...
15.
Brawand D, Wagner C, Li Y, Malinsky M, Keller I, Fan S, et al.
Nature
. 2014 Sep;
513(7518):375-381.
PMID: 25186727
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the...
16.
Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, et al.
Pain
. 2014 Aug;
155(11):2306-22.
PMID: 25168672
Peripheral sensory ganglia contain somata of afferent fibres conveying somatosensory inputs to the central nervous system. Growing evidence suggests that the somatic/perisomatic region of sensory neurons can influence peripheral sensory...
17.
Bradnam K, Fass J, Alexandrov A, Baranay P, Bechner M, Birol I, et al.
Gigascience
. 2013 Jul;
2(1):10.
PMID: 23870653
Background: The process of generating raw genome sequence data continues to become cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished genome sequences remains challenging. Many...
18.
Ross M, Russ C, Costello M, Hollinger A, Lennon N, Hegarty R, et al.
Genome Biol
. 2013 May;
14(5):R51.
PMID: 23718773
Background: DNA sequencing technologies deviate from the ideal uniform distribution of reads. These biases impair scientific and medical applications. Accordingly, we have developed computational methods for discovering, describing and measuring...
19.
Amemiya C, Alfoldi J, Lee A, Fan S, Philippe H, MacCallum I, et al.
Nature
. 2013 Apr;
496(7445):311-6.
PMID: 23598338
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth...
20.
Kirby A, Gnirke A, Jaffe D, Baresova V, Pochet N, Blumenstiel B, et al.
Nat Genet
. 2013 Feb;
45(3):299-303.
PMID: 23396133
Although genetic lesions responsible for some mendelian disorders can be rapidly discovered through massively parallel sequencing of whole genomes or exomes, not all diseases readily yield to such efforts. We...