David Adalsteinsson
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Explore the profile of David Adalsteinsson including associated specialties, affiliations and a list of published articles.
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19
Citations
374
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Recent Articles
1.
Kokkanti A, Atanasiu A, Kolbin D, Adalsteinsson D, Bloom K, Vasquez P
J Chem Phys
. 2024 Nov;
161(20).
PMID: 39575737
We present a novel method for identifying topological features of chromatin domains in live cells using single-particle tracking and topological data analysis (TDA). By applying TDA to particle trajectories, we...
2.
OShaughnessy E, Lam M, Ryken S, Wiesner T, Lukasik K, Zuchero J, et al.
J Cell Sci
. 2024 May;
137(20).
PMID: 38690758
Exocytosis is a fundamental process used by eukaryotes to regulate the composition of the plasma membrane and facilitate cell-cell communication. To investigate exocytosis in neuronal morphogenesis, previously we developed computational...
3.
Kolbin D, Walker B, Hult C, Stanton J, Adalsteinsson D, Gregory Forest M, et al.
Genes (Basel)
. 2023 Dec;
14(12).
PMID: 38137015
Transient DNA loops occur throughout the genome due to thermal fluctuations of DNA and the function of SMC complex proteins such as condensin and cohesin. Transient crosslinking within and between...
4.
Ballard-Kordeliski A, Lee R, OShaughnessy E, Kim P, Jones S, Mackman N, et al.
bioRxiv
. 2023 Sep;
PMID: 37662350
Interplay between platelets, coagulation/fibrinolytic factors, and endothelial cells (ECs) is necessary for effective hemostatic plug formation. This study describes a novel four-dimensional (4D) imaging platform to visualize and quantify hemostatic...
5.
OShaughnessy E, Lam M, Ryken S, Wiesner T, Lukasik K, Zuchero B, et al.
bioRxiv
. 2023 Aug;
PMID: 37546865
Summary Statement: Exocytosis is an essential process by which cells change shape, alter membrane composition, and communicate with other cells. Though all eukaryotic cells carry out exocytosis, the regulation of...
6.
He Y, Adalsteinsson D, Walker B, Lawrimore J, Gregory Forest M, Bloom K
Methods Mol Biol
. 2022 Jan;
2415:211-220.
PMID: 34972957
The application of polymer models to chromosome structure and dynamics is a powerful approach for dissecting functional properties of the chromosome. The models are based on well-established bead-spring models of...
7.
He Y, Lawrimore J, Cook D, Van Gorder E, De Larimat S, Adalsteinsson D, et al.
Nucleic Acids Res
. 2020 Oct;
48(20):11284-11303.
PMID: 33080019
The revolution in understanding higher order chromosome dynamics and organization derives from treating the chromosome as a chain polymer and adapting appropriate polymer-based physical principles. Using basic principles, such as...
8.
Gerbich T, McLaughlin G, Cassidy K, Gerber S, Adalsteinsson D, Gladfelter A
J Cell Biol
. 2020 May;
219(7).
PMID: 32399546
Biomolecular condensation is a way of organizing cytosol in which proteins and nucleic acids coassemble into compartments. In the multinucleate filamentous fungus Ashbya gossypii, the RNA-binding protein Whi3 regulates the...
9.
OShaughnessy E, Stone O, LaFosse P, Azoitei M, Tsygankov D, Heddleston J, et al.
J Cell Biol
. 2019 Aug;
218(9):3153-3160.
PMID: 31444239
Lattice light-sheet microscopy (LLSM) is valuable for its combination of reduced photobleaching and outstanding spatiotemporal resolution in 3D. Using LLSM to image biosensors in living cells could provide unprecedented visualization...
10.
Walker B, Taylor D, Lawrimore J, Hult C, Adalsteinsson D, Bloom K, et al.
PLoS Comput Biol
. 2019 Aug;
15(8):e1007124.
PMID: 31433796
Our understanding of how chromosomes structurally organize and dynamically interact has been revolutionized through the lens of long-chain polymer physics. Major protein contributors to chromosome structure and dynamics are condensin...