Ellen C OShaughnessy
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Explore the profile of Ellen C OShaughnessy including associated specialties, affiliations and a list of published articles.
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10
Citations
135
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Recent Articles
1.
Mutalik S, Ho C, OShaughnessy E, Frasineanu A, Shah A, Gupton S
J Neurochem
. 2025 Jan;
169(1):e70002.
PMID: 39871643
The guidance cue netrin-1 promotes both growth cone attraction and growth cone repulsion. How netrin-1 elicits diverse axonal responses, beyond engaging the netrin receptor DCC and UNC5 family members, remains...
2.
Ballard-Kordeliski A, Lee R, OShaughnessy E, Kim P, Jones S, Pawlinski R, et al.
Blood
. 2024 May;
144(10):1116-1126.
PMID: 38820498
Interplay between platelets, coagulation factors, endothelial cells (ECs), and fibrinolytic factors is necessary for effective hemostatic plug formation. This study describes a 4-dimensional (4D) imaging platform to visualize and quantify...
3.
Mutalik S, OShaughnessy E, Ho C, Gupton S
bioRxiv
. 2024 May;
PMID: 38765979
The guidance cue netrin-1 promotes both growth cone attraction and growth cone repulsion. How netrin-1 elicits these diverse axonal responses, beyond engaging the attractive receptor DCC and repulsive receptors of...
4.
OShaughnessy E, Lam M, Ryken S, Wiesner T, Lukasik K, Zuchero J, et al.
J Cell Sci
. 2024 May;
137(20).
PMID: 38690758
Exocytosis is a fundamental process used by eukaryotes to regulate the composition of the plasma membrane and facilitate cell-cell communication. To investigate exocytosis in neuronal morphogenesis, previously we developed computational...
5.
Ballard-Kordeliski A, Lee R, OShaughnessy E, Kim P, Jones S, Mackman N, et al.
bioRxiv
. 2023 Sep;
PMID: 37662350
Interplay between platelets, coagulation/fibrinolytic factors, and endothelial cells (ECs) is necessary for effective hemostatic plug formation. This study describes a novel four-dimensional (4D) imaging platform to visualize and quantify hemostatic...
6.
OShaughnessy E, Lam M, Ryken S, Wiesner T, Lukasik K, Zuchero B, et al.
bioRxiv
. 2023 Aug;
PMID: 37546865
Summary Statement: Exocytosis is an essential process by which cells change shape, alter membrane composition, and communicate with other cells. Though all eukaryotic cells carry out exocytosis, the regulation of...
7.
Moore R, OShaughnessy E, Shi Y, Nogueira A, Heath K, Hahn K, et al.
Lab Chip
. 2021 Dec;
22(1):136-147.
PMID: 34859808
We present a microfluidic device compatible with high resolution light sheet and super-resolution microscopy. The device is a 150 μm thick chamber with a transparent fluorinated ethylene propylene (FEP) cover...
8.
OShaughnessy E, Stone O, LaFosse P, Azoitei M, Tsygankov D, Heddleston J, et al.
J Cell Biol
. 2019 Aug;
218(9):3153-3160.
PMID: 31444239
Lattice light-sheet microscopy (LLSM) is valuable for its combination of reduced photobleaching and outstanding spatiotemporal resolution in 3D. Using LLSM to image biosensors in living cells could provide unprecedented visualization...
9.
Stefanini L, Lee R, Paul D, OShaughnessy E, Ghalloussi D, Jones C, et al.
Blood
. 2018 Aug;
132(18):1951-1962.
PMID: 30131434
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and...
10.
OShaughnessy E, Sarkar C
Curr Opin Biotechnol
. 2012 Feb;
23(5):785-90.
PMID: 22325791
Signaling pathways lie at the heart of cellular responses to environmental cues. The ability to reconstruct specific signaling modules ex vivo allows us to study their inherent properties in an...