David A Matthews
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Explore the profile of David A Matthews including associated specialties, affiliations and a list of published articles.
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78
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3611
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Recent Articles
1.
Using minor variant genomes and machine learning to study the genome biology of SARS-CoV-2 over time
Dong X, Matthews D, Gallo G, Darby A, Donovan-Banfield I, Goldswain H, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39970290
In infected individuals, viruses are present as a population consisting of dominant and minor variant genomes. Most databases contain information on the dominant genome sequence. Since the emergence of SARS-CoV-2...
2.
Webb I, Erdmann M, Milligan R, Savage M, Matthews D, Davidson A
J Gen Virol
. 2025 Feb;
106(2).
PMID: 39937571
The SARS-CoV-2 genome encodes at least nine accessory proteins, including innate immune antagonist and putative viroporin ORF3a. ORF3a plays a role in many stages of the viral replication cycle, including...
3.
Clark J, Penrice-Randal R, Sharma P, Dong X, Pennington S, Marriott A, et al.
Viruses
. 2024 Jun;
16(6).
PMID: 38932155
COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-2. The coalescence of SARS-CoV-2 with seasonal respiratory viruses, particularly influenza viruses, is a global health concern....
4.
Wasswa J, Perkins M, Matthews D, Zeng T
Environ Sci Technol
. 2024 Apr;
58(18):8020-8031.
PMID: 38629457
Cyanobacterial blooms introduce autochthonous dissolved organic matter (DOM) into aquatic environments, but their impact on surface water photoreactivity has not been investigated through collaborative field sampling with comparative laboratory assessments....
5.
Alruwaili M, Armstrong S, Prince T, Erdmann M, Matthews D, Luu L, et al.
J Virol
. 2023 Nov;
97(11):e0042423.
PMID: 37929963
SARS-CoV-2 has caused a worldwide health and economic crisis. During the course of the pandemic, genetic changes occurred in the virus, which have resulted in new properties of the virus-particularly...
6.
Stewart H, Lu Y, OKeefe S, Valpadashi A, Cruz-Zaragoza L, Michel H, et al.
iScience
. 2023 Oct;
26(11):108080.
PMID: 37860693
The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of...
7.
Matthews D, Milligan R, Wee E, Hanke T
Vaccines (Basel)
. 2023 Jul;
11(7).
PMID: 37515003
We develop candidate HIV-1 vaccines, of which two components, ChAdOx1.tHIVconsv1 (C1) and ChAdOx1.HIVconsv62 (C62), are delivered by the simian adenovirus-derived vaccine vector ChAdOx1. Aberrant adenovirus RNA splicing involving transgene(s) coding...
8.
Goldswain H, Dong X, Penrice-Randal R, Alruwaili M, Shawli G, Prince T, et al.
Genome Biol
. 2023 Mar;
24(1):47.
PMID: 36915185
Background: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the...
9.
Brooks-Pollock E, Northstone K, Pellis L, Scarabel F, Thomas A, Nixon E, et al.
BMC Med
. 2023 Jan;
21(1):25.
PMID: 36658548
Background: Predicting the likely size of future SARS-CoV-2 waves is necessary for public health planning. In England, voluntary "plan B" mitigation measures were introduced in December 2021 including increased home...
10.
Donovan-Banfield I, Milligan R, Hall S, Gao T, Murphy E, Li J, et al.
PLoS One
. 2022 Nov;
17(11):e0276697.
PMID: 36355791
To characterize species of viral mRNA transcripts generated during respiratory syncytial virus (RSV) infection, human fibroblast-like MRC-5 lung cells were infected with subgroup A RSV for 6, 16 and 24...