David A Hildeman
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Explore the profile of David A Hildeman including associated specialties, affiliations and a list of published articles.
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89
Citations
4103
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Recent Articles
1.
Rudman-Melnick V, Vanhoutte D, Stowers K, Sargent M, Adam M, Ma Q, et al.
Sci Rep
. 2024 Nov;
14(1):29307.
PMID: 39592775
Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue...
2.
Pundavela J, Dinglasan S, Touvron M, Hummel S, Hu L, Rizvi T, et al.
Sci Adv
. 2024 Oct;
10(42):eado6342.
PMID: 39413183
Plexiform neurofibromas (PNFs) are benign nerve tumors driven by loss of the tumor suppressor in Schwann cells. PNFs are rich in immune cells, but whether immune cells are necessary for...
3.
Thorman A, Reigle J, Chutipongtanate S, Yang J, Shamsaei B, Pilarczyk M, et al.
Sci Adv
. 2024 Aug;
10(35):eadj3010.
PMID: 39213358
We present an in silico approach for drug discovery, dubbed connectivity enhanced structure activity relationship (ceSAR). Building on the landmark LINCS library of transcriptional signatures of drug-like molecules and gene...
4.
Rudman-Melnick V, Vanhoutte D, Stowers K, Sargent M, Adam M, Ma Q, et al.
Res Sq
. 2024 Aug;
PMID: 39184103
Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue...
5.
Rudman-Melnick V, Vanhoutte D, Stowers K, Sargent M, Adam M, Ma Q, et al.
bioRxiv
. 2024 May;
PMID: 38798483
Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue...
6.
Peters A, DePasquale E, Begum G, Roskin K, Woodle E, Hildeman D
bioRxiv
. 2024 Mar;
PMID: 38464256
Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective...
7.
Khorki M, Shi T, Cianciolo E, Burg A, Chukwuma P, Picarsic J, et al.
Front Immunol
. 2023 Dec;
14:1287546.
PMID: 38143762
Introduction: Significant evidence suggests a connection between transplant rejection and the presence of high levels of pre-existing memory T cells. Viral infection can elicit viral-specific memory T cells that cross-react...
8.
Mahajan S, Alexander A, Koenig Z, Saba N, Prasanphanich N, Hildeman D, et al.
JCI Insight
. 2023 Sep;
8(17).
PMID: 37681414
Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were...
9.
Thomas A, Godarova A, Wayman J, Miraldi E, Hildeman D, Chougnet C
Semin Immunol
. 2023 Aug;
70:101836.
PMID: 37632992
The 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all...
10.
Shi T, Burg A, Caldwell J, Roskin K, Castro-Rojas C, Chukwuma P, et al.
J Clin Invest
. 2023 May;
133(14).
PMID: 37227784
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite...