David A Hildeman
Overview
Explore the profile of David A Hildeman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
89
Citations
4103
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
12.
Thomas A, Wayman J, Almanan M, Bejjani A, Miraldi E, Chougnet C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993647
Our recent data showed that an aberrant IL-10-producing T follicular helper population (Tfh10) accumulates dramatically with age and is associated with age-related declines in vaccine responsiveness. Through single cell gene...
13.
Wayman J, Thomas A, Bejjani A, Katko A, Almanan M, Godarova A, et al.
bioRxiv
. 2023 Mar;
PMID: 36945549
Aging profoundly affects immune-system function, promoting susceptibility to pathogens, cancers and chronic inflammation. We previously identified a population of IL-10-producing, T follicular helper-like cells (" "), linked to suppressed vaccine...
14.
Shanmuganad S, Ferguson A, Paranjpe A, Cianciolo E, Katz J, Herold M, et al.
bioRxiv
. 2023 Mar;
PMID: 36909576
Following their proliferative expansion and differentiation into effector cells like Th1, Tfh, and T central memory precursors (Tcmp), most effector CD4+ T cells die, while some survive and become memory...
15.
Rossi A, Tremblay S, Castro-Rojas C, Burg A, Roskin K, Gehman J, et al.
Am J Transplant
. 2023 Mar;
23(6):759-775.
PMID: 36871629
To date, plasma cell (PC)-targeted therapies have been limited by suboptimal PC depletion and antibody rebound. We hypothesized this is partly because of PC residence in protective bone marrow (BM)...
16.
Shi T, Burg A, Caldwell J, Roskin K, Castro-Rojas C, Chukwuma P, et al.
bioRxiv
. 2023 Feb;
PMID: 36798151
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding. We performed combined single cell...
17.
Thomas A, Lehn M, Janssen E, Hildeman D, Chougnet C
Sci Rep
. 2022 Nov;
12(1):19471.
PMID: 36376530
Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ) plaques in Alzheimer's disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few...
18.
Thomas A, Alarcon P, Divanovic S, Chougnet C, Hildeman D, Moreno-Fernandez M
Front Aging
. 2022 Jul;
2:732414.
PMID: 35822048
Aging and obesity are two conditions characterized by chronic, low-grade inflammation. While both conditions are also associated with dysfunctional immune responses, the shared and distinct underlying mechanisms are just starting...
19.
Shanmuganad S, Hummel S, Varghese V, Hildeman D
J Immunol
. 2022 Jan;
208(3):651-659.
PMID: 34996838
The precursors of TCRαβCD8αα intraepithelial lymphocytes (IEL) arise in the thymus through a complex process of agonist selection. We and others have shown that the proapoptotic protein, Bim, is critical...
20.
Davis G, York A, Bacon W, Lin S, McNeal M, Yarawsky A, et al.
PLoS One
. 2021 Jul;
16(7):e0254667.
PMID: 34260645
The world is currently in a pandemic of COVID-19 (Coronavirus disease-2019) caused by a novel positive-sense, single-stranded RNA β-coronavirus referred to as SARS-CoV-2. Here we investigated rates of SARS-CoV-2 infection...