David A Dorward
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Explore the profile of David A Dorward including associated specialties, affiliations and a list of published articles.
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48
Citations
1270
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Recent Articles
1.
Chau L, Lillico S, Opriessnig T, Blake R, Tardy L, Lee C, et al.
Nat Commun
. 2025 Jan;
16(1):766.
PMID: 39824810
Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human...
2.
Jacobs A, Morley S, Samuel K, Morgan K, Boswell L, Kendall T, et al.
World J Gastroenterol
. 2024 Aug;
30(31):3705-3716.
PMID: 39192998
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), characterised by hepatic lipid accumulation, causes inflammation and oxidative stress accompanied by cell damage and fibrosis. Liver injury (LI) is also frequently reported...
3.
Wang Q, Akram A, Dorward D, Talas S, Monks B, Thum C, et al.
Npj Imaging
. 2024 Jul;
2(1):17.
PMID: 38948152
Label-free autofluorescence lifetime is a unique feature of the inherent fluorescence signals emitted by natural fluorophores in biological samples. Fluorescence lifetime imaging microscopy (FLIM) can capture these signals enabling comprehensive...
4.
Lin S, Tran C, Bandari E, Romagnoli T, Li Y, Chu M, et al.
Int J Surg Pathol
. 2024 Apr;
32(8):1449-1458.
PMID: 38627896
The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in...
5.
Mathieson L, Koppensteiner L, Dorward D, OConnor R, Akram A
Br J Cancer
. 2024 Apr;
130(11):1758-1769.
PMID: 38582812
Background: Cancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibroblast heterogeneity reflects subpopulations of CAFs, which can influence prognosis and treatment...
6.
Fernandes S, Williams E, Finlayson N, Stewart H, Dhaliwal C, Dorward D, et al.
Transl Lung Cancer Res
. 2024 Mar;
13(2):355-361.
PMID: 38496695
Lung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime...
7.
McAllister M, Hall R, Whelan R, Fischer L, Chuah C, Cartlidge P, et al.
Crohns Colitis 360
. 2024 Feb;
6(1):otae003.
PMID: 38352118
Background: Formylated peptide receptor (FPR)-1 is a G-coupled receptor that senses foreign bacterial and host-derived mitochondrial formylated peptides (FPs), leading to innate immune system activation. Aim: We sought to investigate...
8.
Koppensteiner L, Mathieson L, Pattle S, Dorward D, OConnor R, Akram A
J Immunother Cancer
. 2023 Aug;
11(8).
PMID: 37648263
Purpose: An improved mechanistic understanding of immunosuppressive pathways in non-small cell lung cancer (NSCLC) is important to develop novel diagnostic and therapeutic approaches. Here, we investigate the prognostic significance of...
9.
Titmarsh H, von Kriegsheim A, Wills J, OConnor R, Dhaliwal K, Frame M, et al.
Front Oncol
. 2023 Jul;
13:1194515.
PMID: 37397358
Introduction: The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and...
10.
Valanciute A, Mathieson L, OConnor R, Scott J, Vendrell M, Dorward D, et al.
Cancers (Basel)
. 2022 Sep;
14(17).
PMID: 36077656
Augmenting T cell mediated tumor killing via immunogenic cancer cell death (ICD) is the cornerstone of emerging immunotherapeutic approaches. We investigated the potential of methylene blue photodynamic therapy (MB-PDT) to...