Christopher Haslett
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Explore the profile of Christopher Haslett including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
3783
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Recent Articles
1.
McHugh B, Stephen J, Robb C, Fox S, Kipari T, Cartwright J, et al.
Front Cell Dev Biol
. 2022 Jun;
10:905315.
PMID: 35693926
Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis and enhance the resolution of inflammation in a number of models. This class of compounds are...
2.
Mills B, Megia-Fernandez A, Norberg D, Duncan S, Marshall A, Akram A, et al.
Eur J Nucl Med Mol Imaging
. 2020 Sep;
48(3):800-807.
PMID: 32915268
Purpose: The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this,...
3.
Felton J, Dorward D, Cartwright J, Potey P, Robb C, Gui J, et al.
Thorax
. 2020 Apr;
75(7):600-605.
PMID: 32303624
Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1...
4.
Zhang A, Lacy-Hulbert A, Anderton S, Haslett C, Savill J
Am J Pathol
. 2020 Mar;
190(6):1224-1235.
PMID: 32201264
Intratracheal instillation of apoptotic cells enhances resolution of experimental lung inflammation by incompletely understood mechanisms. We report that this intervention induces functional regulatory T lymphocytes (Tregs) in mouse lung experimentally...
5.
Akram A, Avlonitis N, Scholefield E, Vendrell M, McDonald N, Aslam T, et al.
Sci Rep
. 2019 Jun;
9(1):8422.
PMID: 31182770
Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom...
6.
Akram A, Chankeshwara S, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, et al.
Sci Transl Med
. 2018 Oct;
10(464).
PMID: 30355797
Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical...
7.
Humphries D, ONeill S, Scholefield E, Dorward D, MacKinnon A, Rossi A, et al.
Crit Care Med
. 2018 Jun;
46(9):e937-e944.
PMID: 29957711
Objectives: Mild traumatic brain injury in the form of concussion is extremely common, and the potential effects on pulmonary priming have been underestimated. The aim of this study was to...
8.
Akram A, Avlonitis N, Lilienkampf A, Perez-Lopez A, McDonald N, Chankeshwara S, et al.
Chem Sci
. 2018 Jun;
6(12):6971-6979.
PMID: 29861935
The immediate detection of the presence of bacteria in the distal human lung is of significant clinical utility. Herein we describe the development and optimization of a bacterial binding fragment...
9.
Felton J, Lucas C, Dorward D, Duffin R, Kipari T, Vermeren S, et al.
J Allergy Clin Immunol
. 2018 Feb;
142(6):1884-1893.e6.
PMID: 29428392
Background: Eosinophils play a central role in propagation of allergic diseases, including asthma. Both recruitment and retention of eosinophils regulate pulmonary eosinophilia, but the question of whether alterations in apoptotic...
10.
Gray R, Hardisty G, Regan K, Smith M, Robb C, Duffin R, et al.
Thorax
. 2017 Sep;
73(2):134-144.
PMID: 28916704
Background: Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is...