David A Brenner
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Explore the profile of David A Brenner including associated specialties, affiliations and a list of published articles.
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279
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23369
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Recent Articles
11.
Li N, Li X, Ding Y, Liu X, Diggle K, Kisseleva T, et al.
Biomedicines
. 2023 Dec;
11(12.
PMID: 38137501
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they...
12.
Brenner D
Hepatology
. 2023 Nov;
81(1):304-311.
PMID: 37934631
The Food and Drug Administration (FDA) Modernization Act 2.0 "allows for alternatives to animal testing for purposes of drug and biological product applications." This provides an opportunity to develop and...
13.
Kim H, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Sep;
17(1):93-106.
PMID: 37743012
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or...
14.
El-Kareh R, Brenner D, Longhurst C
Learn Health Syst
. 2023 Jul;
7(3):e10351.
PMID: 37448457
Multiple independent frameworks to support continuous improvement have been proposed to guide healthcare organizations. Two of the most visible are High-reliability Health care, (Chassin et al., 2013) which is emphasized...
15.
Liu X, Lam K, Zhao H, Sakane S, Kim H, Eguileor A, et al.
STAR Protoc
. 2023 Jul;
4(3):102391.
PMID: 37405925
Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and...
16.
Liu X, Brenner D, Kisseleva T
Methods Mol Biol
. 2023 May;
2669:221-232.
PMID: 37247063
Liver fibrosis of different etiologies is characterized by activation of hepatic stellate cells (aHSCs) into collagen type I secreting myofibroblasts, which produce fibrous scar and make the liver fibrotic. aHSCs...
17.
Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, et al.
Cell Host Microbe
. 2023 Mar;
31(3):389-404.e7.
PMID: 36893735
Alcohol-associated liver disease is accompanied by intestinal mycobiome dysbiosis, yet the impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T helper 17 (Th17) cells are increased in...
18.
Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, et al.
Biology (Basel)
. 2022 Nov;
11(11).
PMID: 36358290
Fibrosis is a common consequence of abnormal wound healing, which is characterized by infiltration of myofibroblasts and formation of fibrous scar. In liver fibrosis, activated Hepatic Stellate Cells (aHSCs) and...
19.
Meurer S, Brenner D, Weiskirchen R
PLoS One
. 2022 Sep;
17(9):e0274219.
PMID: 36067186
Misidentification, cross-contamination and genetic drift of continuous animal cell lines are persistent problems in biomedical research, leading to erroneous results and inconsistent or invalidated studies. The establishment of immortalized hepatic...
20.
Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, et al.
Semin Liver Dis
. 2022 Aug;
42(3):233-249.
PMID: 36001995
Nonalcoholic liver disease is a component of metabolic syndrome associated with obesity, insulin resistance, and hyperlipidemia. Excessive alcohol consumption may accelerate the progression of steatosis, steatohepatitis, and fibrosis. While simple...