Keiko Iwaisako
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Explore the profile of Keiko Iwaisako including associated specialties, affiliations and a list of published articles.
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78
Citations
3106
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Recent Articles
1.
Tsuji S, Mizukami S, Sakamoto A, Takemoto K, Seto T, Uehara K, et al.
Sci Rep
. 2025 Feb;
15(1):6197.
PMID: 39979342
Osteoclasts are specialized cells essential for bone resorption, a crucial process in bone remodeling, and dysregulation of osteoclastogenesis can lead to pathological bone loss such as osteoporosis and rheumatoid arthritis....
2.
Seto T, Yukata K, Tsuji S, Takeshima Y, Honda T, Sakamoto A, et al.
Biochem Biophys Res Commun
. 2025 Jan;
747():151312.
PMID: 39799866
Impaired fracture healing in diabetic patients leads to prolonged morbidity and increased healthcare costs. Methylglyoxal (MG), a reactive metabolite elevated in diabetes, is implicated in various complications, but its direct...
3.
Yasumizu Y, Hagiwara M, Umezu Y, Fuji H, Iwaisako K, Asagiri M, et al.
NAR Cancer
. 2024 May;
6(2):zcae022.
PMID: 38751935
DNA methylation is a pivotal epigenetic modification that defines cellular identity. While cell deconvolution utilizing this information is considered useful for clinical practice, current methods for deconvolution are limited in...
4.
Li X, Koyama Y, Taura K, Nishio T, Yoh T, Nishino H, et al.
Hepatol Res
. 2024 Mar;
54(9):817-826.
PMID: 38430513
Background And Aim: Autotaxin (ATX) is an extracellular lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine into lysophosphatidic acid (LPA). Recent accumulating evidence indicates the biological roles of ATX in...
5.
Hori Y, Yoh T, Nishino H, Okura K, Kurimoto M, Takamatsu Y, et al.
Carcinogenesis
. 2023 Dec;
45(3):119-130.
PMID: 38123365
The role of the ferroptosis-related gene glutathione peroxidase 4 (GPX4) in oncology has been extensively investigated. However, the clinical implications of GPX4 in patients with intrahepatic cholangiocarcinoma (ICC) remain unknown....
6.
Kozuki S, Kabata M, Sakurai S, Iwaisako K, Nishimura T, Toi M, et al.
Commun Biol
. 2023 Dec;
6(1):1226.
PMID: 38049528
The maternal liver is challenged by metabolic demands throughout pregnancy. However, hepatocyte dynamics and their physiological significance in pregnancy remain unclear. Here, we show in mice that hepatocyte proliferation is...
7.
Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, et al.
Biology (Basel)
. 2022 Nov;
11(11).
PMID: 36358290
Fibrosis is a common consequence of abnormal wound healing, which is characterized by infiltration of myofibroblasts and formation of fibrous scar. In liver fibrosis, activated Hepatic Stellate Cells (aHSCs) and...
8.
Kanemitsu E, Zhao X, Iwaisako K, Inoue A, Takeuchi A, Yagi S, et al.
Transl Res
. 2022 Nov;
255:26-36.
PMID: 36347491
Cold storage is widely used to preserve an organ for transplantation; however, a long duration of cold storage negatively impacts graft function. Unfortunately, the mechanisms underlying cold exposure remain unclear....
9.
Toda R, Seo S, Uemoto Y, Morino K, Nishino H, Nakamura N, et al.
Hepatol Res
. 2022 Sep;
53(2):145-159.
PMID: 36149410
Aim: Sinusoidal obstruction syndrome (SOS) induced by oxaliplatin-including chemotherapies (OXCx) is associated with impaired hepatic reserve and higher morbidity after hepatic resection. However, in the absence of an appropriate animal...
10.
Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, et al.
FEBS Open Bio
. 2022 Sep;
12(12):2122-2135.
PMID: 36114826
Cholangiocarcinoma (CC) has a poor prognosis and different driver genes depending on the site of onset. Intrahepatic CC is the second-most common liver cancer after hepatocellular carcinoma, and novel therapeutic...