Daryl L Richie
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Explore the profile of Daryl L Richie including associated specialties, affiliations and a list of published articles.
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22
Citations
494
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Recent Articles
1.
White A, Craig A, Richie D, Corley C, Sadek S, Barton H, et al.
J Neuroimmunol
. 2024 Oct;
397:578468.
PMID: 39461120
A plethora of evidence supports that nicotine, the primary alkaloid in tobacco products that is generally accepted for maintaining use, is immunoregulatory and may function as an immunosuppressant. Women have...
2.
Lapointe G, Skepper C, Holder L, Armstrong D, Bellamacina C, Blais J, et al.
J Med Chem
. 2021 Apr;
64(9):6329-6357.
PMID: 33929852
Herein, we describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV binding to, and stabilization of, DNA cleavage complexes. Optimization of this...
3.
Skepper C, Armstrong D, Balibar C, Bauer D, Bellamacina C, Benton B, et al.
J Med Chem
. 2020 Jul;
63(14):7773-7816.
PMID: 32634310
Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase...
4.
Mostafavi M, Wang L, Xie L, Takeoka K, Richie D, Casey F, et al.
mSphere
. 2018 Nov;
3(5).
PMID: 30381354
Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer...
5.
Richie D, Wang L, Chan H, De Pascale G, Six D, Wei J, et al.
PLoS One
. 2018 Mar;
13(3):e0193851.
PMID: 29505586
Acinetobacter baumannii ATCC 19606 can grow without lipooligosaccharide (LOS). Lack of LOS can result from disruption of the early lipid A biosynthetic pathway genes lpxA, lpxC or lpxD. Although LOS...
6.
Wei J, Richie D, Mostafavi M, Metzger 4th L, Rath C, Sawyer W, et al.
mSphere
. 2017 Aug;
2(4).
PMID: 28815210
ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented...
7.
Richie D, Takeoka K, Bojkovic J, Metzger 4th L, Rath C, Sawyer W, et al.
PLoS One
. 2016 Aug;
11(8):e0160918.
PMID: 27526195
The lipid A moiety of lipopolysaccharide (LPS) is the main constituent of the outer leaflet of the Gram-negative bacterial outer membrane (OM) and is essential in many Gram-negative pathogens. An...
8.
Smith T, Richie D, Tao J
Methods Mol Biol
. 2016 Jun;
1439:171-9.
PMID: 27316995
Due to the advancements in modern medicine that have resulted in an increased number of immunocompromised individuals, the incidences and the associated mortality of invasive aspergillosis have continued to rise...
9.
Bojkovic J, Richie D, Six D, Rath C, Sawyer W, Hu Q, et al.
J Bacteriol
. 2015 Dec;
198(4):731-41.
PMID: 26668262
Unlabelled: Lipid A on the Gram-negative outer membrane (OM) is synthesized in the cytoplasm by the Lpx pathway and translocated to the OM by the Lpt pathway. Some Acinetobacter baumannii...
10.
Ross A, Benton B, Chin D, De Pascale G, Fuller J, Leeds J, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3468-75.
PMID: 26189081
We describe the synthesis and evaluation of a library of variably-linked ciprofloxacin dimers. These structures unify and expand on the use of fluoroquinolones as probes throughout the antibiotic literature. A...