Darren N Saunders
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Explore the profile of Darren N Saunders including associated specialties, affiliations and a list of published articles.
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58
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2043
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Recent Articles
1.
Small L, Nguyen T, Larance M, Saunders D, Hoy A, Schmitz-Peiffer C, et al.
J Lipid Res
. 2024 Nov;
65(12):100687.
PMID: 39490929
De novo lipogenesis (DNL) has been implicated in the development and progression of liver steatosis. Hepatic DNL is strongly influenced by dietary macronutrient composition with diets high in carbohydrate increasing...
2.
Lambert-Smith I, Shephard V, McAlary L, Yerbury J, Saunders D
Sci Rep
. 2024 Jun;
14(1):13844.
PMID: 38879591
Disrupted proteome homeostasis (proteostasis) in amyotrophic lateral sclerosis (ALS) has been a major focus of research in the past two decades. However, the proteostasis processes that become disturbed in ALS...
3.
Van Woerkom A, Harney D, Nagarajan S, Hakeem-Sanni M, Lin J, Hooke M, et al.
Am J Physiol Endocrinol Metab
. 2024 Apr;
326(6):E842-E855.
PMID: 38656127
Fatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed...
4.
Farrawell N, Bax M, McAlary L, McKenna J, Maksour S, Do-Ha D, et al.
Hum Mol Genet
. 2023 May;
32(14):2386-2398.
PMID: 37220877
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that share pathological features, including the aberrant accumulation of ubiquitinated protein inclusions within motor neurons. Previously, we have...
5.
Lambert-Smith I, Saunders D, Yerbury J
Prog Biophys Mol Biol
. 2022 Jun;
174:3-27.
PMID: 35716729
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disease that results from the loss of both upper and lower motor neurons. It is the most common motor...
6.
Rodrigo C, Tedla N, Thomas S, Polly P, Herbert C, Velan G, et al.
Med Sci Educ
. 2021 Aug;
29(2):357-361.
PMID: 34457492
Introduction: Narratives (as opposed to stories) can assess multiple facets of the same problem through the viewpoints of different characters. Methods: Narratives related to three cancer patients, from diagnosis to...
7.
Farrawell N, McAlary L, Lum J, Chisholm C, Warraich S, Blair I, et al.
iScience
. 2020 Nov;
23(11):101700.
PMID: 33196025
A major feature of amyotrophic lateral sclerosis (ALS) pathology is the accumulation of ubiquitin (Ub) into intracellular inclusions. This sequestration of Ub may reduce the availability of free Ub, disrupting...
8.
Amberg A, Saunders D
PLoS One
. 2020 Nov;
15(11):e0242133.
PMID: 33166352
Cancer research in the news is often associated with sensationalised and inaccurate reporting, which may give rise to false hopes and expectations. The role of study selection for cancer-related news...
9.
Belfiore L, Saunders D, Ranson M, Vine K
Pharmaceutics
. 2020 Jul;
12(7).
PMID: 32645963
The urokinase plasminogen activator and its receptor (uPA/uPAR) are biomarkers for metastasis, especially in triple-negative breast cancer. We prepared anti-mitotic -alkylisatin (-AI)-loaded liposomes functionalized with the uPA/uPAR targeting ligand, plasminogen...
10.
Cipponi A, Goode D, Bedo J, McCabe M, Pajic M, Croucher D, et al.
Science
. 2020 Jun;
368(6495):1127-1131.
PMID: 32499442
In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes may underpin progression and therapeutic failure in human cancer. We describe SIM in multiple...