R William Broadhurst
Overview
Explore the profile of R William Broadhurst including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
618
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Moretto L, Heylen R, Holroyd N, Vance S, Broadhurst R
Sci Rep
. 2019 Feb;
9(1):2325.
PMID: 30787330
Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a series of enzyme active sites....
2.
Bruce H, Du D, Matak-Vinkovic D, Bandyra K, Broadhurst R, Martin E, et al.
Nucleic Acids Res
. 2017 Nov;
46(1):387-402.
PMID: 29136196
The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA metabolism of Escherichia coli and numerous other bacterial species including pathogens. At the core of...
3.
Moretto L, Vance S, Heames B, Broadhurst R
Chem Commun (Camb)
. 2017 Oct;
53(83):11457-11460.
PMID: 28980673
Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the...
4.
Gonzalez G, Hardwick S, Maslen S, Skehel J, Holmqvist E, Vogel J, et al.
RNA
. 2017 Feb;
23(5):696-711.
PMID: 28193673
The protein ProQ has recently been identified as a global small noncoding RNA-binding protein in , and a similar role is anticipated for its numerous homologs in divergent bacterial species....
5.
Murphy A, Hong H, Vance S, Broadhurst R, Leadlay P
Chem Commun (Camb)
. 2016 Jun;
52(54):8373-6.
PMID: 27307197
An in vitro model system based on a ketosynthase domain of the erythromycin polyketide synthase was used to probe the apparent substrate tolerance of ketosynthase domains of the mycolactone polyketide...
6.
Ali M, Broadhurst R
PLoS One
. 2013 Mar;
8(3):e57345.
PMID: 23520467
The STAR protein family member Quaking is essential for early development in vertebrates. For example, in oligodendrocyte cells it regulates the splicing, localization, translation and lifetime of a set of...
7.
Hardwick S, Chan V, Broadhurst R, Luisi B
Nucleic Acids Res
. 2010 Oct;
39(4):1449-59.
PMID: 20952404
In many bacterial species, the multi-enzyme RNA degradosome assembly makes key contributions to RNA metabolism. Powering the turnover of RNA and the processing of structural precursors, the RNA degradosome has...
8.
Tran L, Broadhurst R, Tosin M, Cavalli A, Weissman K
Chem Biol
. 2010 Jul;
17(7):705-16.
PMID: 20659683
Numerous natural products of clinical value are biosynthesized by polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), which are multienzymes comprising modules of catalytic domains. The key players in each...
9.
Cheung M, Maguire M, Stevens T, Broadhurst R
J Magn Reson
. 2009 Dec;
202(2):223-33.
PMID: 20015671
This paper introduces DANGLE, a new algorithm that employs Bayesian inference to estimate the likelihood of all possible values of the backbone dihedral angles phi and psi for each residue...
10.
Richter C, Nietlispach D, Broadhurst R, Weissman K
Nat Chem Biol
. 2007 Dec;
4(1):75-81.
PMID: 18066054
Hybrid multienzyme systems composed of polyketide synthase (PKS) and nonribosomal polypeptide synthetase (NRPS) modules direct the biosynthesis of clinically valuable natural products in bacteria. The fidelity of this process depends...