Dar-Chone Chow
Overview
Explore the profile of Dar-Chone Chow including associated specialties, affiliations and a list of published articles.
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26
Citations
980
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Recent Articles
1.
Chow D, Rice K, Huang W, Atmar R, Palzkill T
ACS Infect Dis
. 2016 Oct;
2(12):969-979.
PMID: 27756125
The β-lactamase inhibitory protein (BLIP) binds and inhibits a wide range of class A β-lactamases including the TEM-1 β-lactamase (K = 0.5 nM), which is widely present in Gram-negative bacteria,...
2.
Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard D, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(18):4970-5.
PMID: 27084884
Protein-protein interactions (PPIs) play a central role in most biological processes, and therefore represent an important class of targets for therapeutic development. However, disrupting PPIs using small-molecule inhibitors (SMIs) is...
3.
Wang L, Yu Y, Chow D, Yan F, Hsu C, Stossi F, et al.
Cancer Cell
. 2015 Aug;
28(2):240-52.
PMID: 26267537
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs)...
4.
Stojanoski V, Chow D, Fryszczyn B, Hu L, Nordmann P, Poirel L, et al.
Biochemistry
. 2015 May;
54(21):3370-80.
PMID: 25938261
OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates. OXA-163 differs from OXA-48 by one...
5.
Stojanoski V, Chow D, Hu L, Sankaran B, Gilbert H, Prasad B, et al.
J Biol Chem
. 2015 Feb;
290(16):10382-94.
PMID: 25713062
β-Lactamases are bacterial enzymes that hydrolyze β-lactam antibiotics. TEM-1 is a prevalent plasmid-encoded β-lactamase in Gram-negative bacteria that efficiently catalyzes the hydrolysis of penicillins and early cephalosporins but not oxyimino-cephalosporins....
6.
Humphreys A, Tan J, Peng R, Benton S, Qin X, Worley K, et al.
PLoS One
. 2015 Feb;
10(2):e0116318.
PMID: 25658336
Asian elephant (Elephas maximus) immunity is poorly characterized and understood. This gap in knowledge is particularly concerning as Asian elephants are an endangered species threatened by a newly discovered herpesvirus...
7.
Viskovska M, Anish R, Hu L, Chow D, Hurwitz A, Brown N, et al.
J Virol
. 2014 Aug;
88(21):12866-81.
PMID: 25165107
Unlabelled: Replication and packaging of the rotavirus genome occur in cytoplasmic compartments called viroplasms, which form during virus infection. These processes are orchestrated by yet-to-be-understood complex networks of interactions involving...
8.
Yan F, Yu Y, Chow D, Palzkill T, Madoux F, Hodder P, et al.
PLoS One
. 2014 Apr;
9(4):e95243.
PMID: 24743578
Members of the steroid receptor coactivator (SRC) family are overexpressed in numerous types of cancers. In particular, steroid receptor coactivator 3 (SRC-3) has been recognized as a critical coactivator associated...
9.
Wang Y, Lonard D, Yu Y, Chow D, Palzkill T, Wang J, et al.
Cancer Res
. 2014 Jan;
74(5):1506-1517.
PMID: 24390736
Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery. Coactivators have been implicated in cancer cell proliferation, invasion, and metastasis,...
10.
Brown N, Chow D, Ruprecht K, Palzkill T
J Biol Chem
. 2013 Apr;
288(24):17156-66.
PMID: 23625930
The interactions between β-lactamase inhibitory proteins (BLIPs) and β-lactamases have been used as model systems to understand the principles of affinity and specificity in protein-protein interactions. The most extensively studied...