Bert W OMalley
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Explore the profile of Bert W OMalley including associated specialties, affiliations and a list of published articles.
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323
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13479
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Recent Articles
1.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, et al.
Cell
. 2024 Oct;
187(25):7248-7266.e34.
PMID: 39419025
Chemotherapy is often combined with immune checkpoint inhibitor (ICIs) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms...
2.
McClendon L, Lanz R, Panigrahi A, Gomez K, Bolt M, Liu M, et al.
J Mol Cell Cardiol
. 2024 Jul;
194:70-84.
PMID: 38969334
We recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are abundantly expressed in cardiac fibroblasts (CFs) and their activation with the SRC small molecule stimulator MCB-613 improves...
3.
Gilad Y, Shimon O, Han S, Lonard D, OMalley B
Front Immunol
. 2024 May;
15:1389041.
PMID: 38698860
Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with...
4.
Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, et al.
PLoS One
. 2024 Apr;
19(4):e0289902.
PMID: 38683834
Mantle cell lymphoma (MCL) has a poor prognosis and high relapse rates despite current therapies, necessitating novel treatment regimens. Inhibition of SRC-3 show effectiveness in vivo and in vitro in...
5.
Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, et al.
J Med Chem
. 2024 Mar;
67(7):5333-5350.
PMID: 38551814
Steroid receptor coactivator 3 (SRC-3) is a critical mediator of many intracellular signaling pathways that are crucial for cancer proliferation and metastasis. In this study, we performed structure-activity relationship exploration...
6.
Dastgheyb S, Dreyfuss A, LaRiviere M, Mohiuddin J, Baumann B, Shabason J, et al.
Adv Radiat Oncol
. 2024 Mar;
9(5):101456.
PMID: 38550376
Purpose: The purpose of this study was to evaluate the feasibility and safety of dose-escalated proton beam therapy for treating chordomas and chondrosarcomas of the skull base and spine. Methods:...
7.
Chadchan S, Popli P, Liao Z, Andreas E, Dias M, Wang T, et al.
Nat Commun
. 2024 Mar;
15(1):1947.
PMID: 38431630
Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid...
8.
Maurya V, Szwarc M, Lonard D, Kommagani R, Wu S, OMalley B, et al.
FASEB J
. 2023 Nov;
37(12):e23313.
PMID: 37962238
Although we have shown that steroid receptor coactivator-2 (SRC-2), a member of the p160/SRC family of transcriptional coregulators, is essential for decidualization of both human and murine endometrial stromal cells,...
9.
Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, et al.
Science
. 2023 Sep;
381(6662):eabn4180.
PMID: 37676964
Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of...
10.
Han S, Jain P, Gilad Y, Xia Y, Sung N, Park M, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(23):e2221707120.
PMID: 37253006
Steroid receptor coactivator 3 (SRC-3) is most strongly expressed in regulatory T cells (Tregs) and B cells, suggesting that it plays an important role in the regulation of Treg function....